{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:56:38Z","timestamp":1785783398495,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Malignant tumors arising from benign eccrine spiradenomas are rare. They are divided by morphology into low\u2010grade and high\u2010grade spiradenocarcinomas, with prognosis and metastatic potential closely linked to their histopathologic features. Tumors with low\u2010grade morphology are known for their indolent behavior, with only two reported instances of metastatic spread. We report herein two further low\u2010grade metastatic spiradenocarcinomas resulting in distant metastasis. Both tumors showed a background of a benign spiradenoma and subtle histopathologic signs of malignant transformation, characterized by loss of the dual\u2010cell population, up to moderate cytological atypia and increased mitotic activity. Both patients developed metastases to the lungs years after the initial presentation, and one showed additional lymph nodal disease. We show that even the morphologically low\u2010grade tumors may rarely show more aggressive behavior. Although often challenging, recognition of the morphologically low\u2010grade malignant spiradenocarcinoma and long\u2010term follow\u2010up of the patients are important to detect metastatic disease.<\/jats:p>","DOI":"10.1111\/cup.14388","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T03:48:37Z","timestamp":1673236117000},"page":"642-646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Distant metastasis from morphologically low\u2010grade spiradenocarcinoma: A report of two cases"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6751-4159","authenticated-orcid":false,"given":"Katherine","family":"Lach","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Gharpuray\u2010Pandit","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology Royal Preston Hospital  Preston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Franko","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0089-0352","authenticated-orcid":false,"given":"Thomas","family":"Brenn","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Arnie Charbonneau Cancer Institute, Cumming School of Medicine University of Calgary  Calgary Alberta 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