{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T22:04:17Z","timestamp":1781733857225,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cutaneous clear cell sarcomas may be confused with melanomas as a result of overlapping histopathology and immunohistochemical staining. We report a case of a 41\u2010year\u2010old woman with a purported history of acral melanoma of the great toe. Twenty\u2010one months after excision of the primary tumor, the patient developed a groin mass, diagnosed as metastatic melanoma on excision. Five months later, a biopsy of a lung mass was reported as metastatic melanoma. The patient was referred to our institution for treatment, which prompted molecular testing on the groin metastasis by targeted next\u2010generation sequencing. Molecular testing results revealed <jats:italic>TP53<\/jats:italic> and <jats:italic>TERT<\/jats:italic> promoter mutations and the absence of <jats:italic>BRAF<\/jats:italic>, <jats:italic>KRAS<\/jats:italic>, and <jats:italic>KIT<\/jats:italic> mutations; it also revealed an <jats:italic>EWSR1::CREM<\/jats:italic> fusion that was confirmed by Archer FusionPlex. The alleged acral melanoma was re\u2010reviewed, showing an invasive amelanotic spindle cell neoplasm in the dermis with neoplastic nests at the dermal\u2013epidermal junction; the tumor cells expressed markers of melanocytic differentiation but were negative for PRAME and <jats:italic>BRAF<\/jats:italic> immunohistochemical staining. Molecular testing of the toe and lung metastasis revealed the same <jats:italic>EWSR1::CREM<\/jats:italic> fusion. In light of the molecular findings, the diagnosis was revised to a primary acral compound clear cell sarcoma with <jats:italic>EWSR1::CREM<\/jats:italic> fusion.<\/jats:p>","DOI":"10.1111\/cup.14390","type":"journal-article","created":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T10:54:47Z","timestamp":1673693687000},"page":"1065-1069","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Compound clear cell sarcoma with <i>EWSR1::CREM<\/i> fusion"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4784-1977","authenticated-orcid":false,"given":"Philippa","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York 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