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The condition is identified under several names such as \u201cmusic box spine keratosis\u201d and \u201cpalmoplantar filiform hyperkeratosis,\u201d creating ambiguity in the diagnostic and histopathologic features of the disease. In this study, we reviewed 84 cases of SpK to examine patient demographics, medical history, clinical and histopathological descriptions, and sporadic versus hereditary onset. Notably, the most used histopathological terms were \u201cparakeratosis\u201d and \u201chypogranulosis,\u201d and the most used clinical terms were \u201cspine\u201d and \u201chyperpigmented.\u201d The average age at presentation was 60.1\u2009years with the majority of cases in males. Only 29.8% of cases were associated with a family history of SpK and underlying malignancies were present in 28.6% of cases. This review investigates the frequency of histopathologic and clinical terms used to describe SpK to provide insight into the clinical and histopathological characteristics of this rarely reported condition.<\/jats:p>","DOI":"10.1111\/cup.14392","type":"journal-article","created":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T05:56:34Z","timestamp":1673675794000},"page":"371-377","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Spiny keratoderma: A review of case reports and histopathological descriptions"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0857-4848","authenticated-orcid":false,"given":"Stephanie A.","family":"Valek","sequence":"first","affiliation":[{"name":"The University of Texas Health Science Center at Houston John P. and Kathrine G. McGovern Medical School  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areebah S.","family":"Ahmad","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston John P. and Kathrine G. McGovern Medical School  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan A.","family":"Rousseau","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston John P. and Kathrine G. McGovern Medical School  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashid M.","family":"Rashid","sequence":"additional","affiliation":[{"name":"Mosaic Dermatology  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1971.04000240106016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20104632.2012.05488.x"},{"issue":"6","key":"e_1_2_8_4_1","first-page":"389","article-title":"Spiny keratoderma: case report, classification, and treatment of music box spine dermatoses","volume":"54","author":"McGovern TW","year":"1994","journal-title":"Cutis"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.04.081"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13248"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000251872"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.1976.tb15538.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.125.10.1432"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.1989.tb01805.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1989.01670180088013"},{"issue":"6","key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"478","DOI":"10.2340\/00015555-7047482","article-title":"Punctate porokeratotic keratoderma: some pathogenetic analyses of hyperproliferation and parakeratosis","volume":"70","author":"Kondo S","year":"1990","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190\u20109622(92)70128\u20103"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102230.1994.tb01142.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20103083.1994.tb00385.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190\u20109622(95)91429\u20103"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190\u20109622(96)90084\u20105"},{"issue":"7","key":"e_1_2_8_18_1","first-page":"519","article-title":"Palmoplantar filiform hyperkeratosis with Darier's disease. 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