{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:18:00Z","timestamp":1778498280679,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Poromatosis is a rare condition characterized by the development of multiple poromas, mainly reported in patients with a history of malignancy. Recently, frequent <jats:italic>YAP1::MAML2<\/jats:italic> and <jats:italic>YAP1::NUTM1<\/jats:italic> fusions have been described in poromas and porocarcinomas. To date, the molecular features of poromatosis have been investigated in one patient only, wherein the poromas harbored <jats:italic>YAP1::MAML2<\/jats:italic> fusions. Herein, we present two additional cases of poromatosis with <jats:italic>YAP1::MAML2<\/jats:italic> fusions. Case 1: An 81\u2010year\u2010old woman presented with nine papules on the scalp, trunk, and extremities persisting for a year. She had a history of breast cancer, with no information on the treatment. Seven papules were excised. Case 2: A 65\u2010year\u2010old woman presented with 21 lesions on her trunk and lower extremities persisting for 2\u2009years. She had been diagnosed with breast cancer 11\u2009years prior and had undergone partial mastectomy, radiotherapy, chemotherapy, and endocrine therapy. Four lesions were excised. All 11 lesions in both patients were histopathologically similar: anastomosing cords and strands extending from the epidermis, and poroid and cuticular cell proliferation with interspersed small ducts. The tumors showed diffuse nuclear expression of YAP1 N\u2010terminus and loss of YAP1 C\u2010terminus expression. No lesions showed NUT immunopositivity. Sanger sequencing identified <jats:italic>YAP1::MAML2<\/jats:italic> fusions in the poromas of both patients.<\/jats:p>","DOI":"10.1111\/cup.14401","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T16:03:51Z","timestamp":1675267431000},"page":"695-701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<i>YAP1::MAML2<\/i> fusions in poromatosis: A report of two patients"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2587-2206","authenticated-orcid":false,"given":"Yasuhiro","family":"Mitsui","sequence":"first","affiliation":[{"name":"Department of Dermatology Nara Medical University School of Medicine  Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3415-891X","authenticated-orcid":false,"given":"Kohei","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nara Medical University School of Medicine  Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4165-1809","authenticated-orcid":false,"given":"Keisuke","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital  Tokyo Japan"},{"name":"Department of Pathology Itabashi Central Clinical Laboratory  Tokyo Japan"},{"name":"Department of Anatomic Pathology Tokyo Medical University  Tokyo Japan"},{"name":"Department of Diagnostic Pathology Shizuoka Cancer Center Hospital  Shizuoka Japan"},{"name":"Department of Diagnostic Pathology and Cytology Osaka International Cancer Institute  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Nara Medical University School of Medicine  Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Nakamura\u2010Nishimura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nara Medical University School of Medicine  Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumi","family":"Mashiba","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery Nara Medical University School of Medicine  Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1971-9835","authenticated-orcid":false,"given":"Hideo","family":"Asada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nara Medical University School of Medicine  Kashihara 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