{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:17:17Z","timestamp":1770909437206,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,12]],"date-time":"2023-03-12T00:00:00Z","timestamp":1678579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cutaneous <jats:italic>VCL::ALK<\/jats:italic> fusion spindle (ovoid) cell tumor is unique. Recently emerged <jats:italic>RAS::MAP<\/jats:italic> tyrosine kinase fusion sarcomas more commonly involve subcutis, skeletal muscle and even bone. We share our experience with a novel cutaneous <jats:italic>VCL::ALK<\/jats:italic> spindle cell tumor. An 11\u2010year\u2010old male presented with a back pedunculated pink\u2013red papule thought to be a pyogenic granuloma. Biopsy histopathology revealed an epithelial collarette with pedunculated tumor extending to deep dermis\/subcutis interface. The combination of spindled and epithelioid cells, an ovoid myopericytoid appearance within myxoid to collagenous stroma, low to moderate MIB1 and focal S100 protein without SOX10 immunostaining, were suggestive of a novel <jats:italic>RAS::MAPK<\/jats:italic> tyrosine kinase fusion sarcoma that is well described. ALK immunostain being positive, a next\u2010generation sequencing comprehensive fusion panel was performed to reveal a <jats:italic>VCL::ALK<\/jats:italic> fusion. While epithelioid fibrous histiocytoma shares this fusion and similar dermal location and collarette pedunculation, this and other entities were excluded by older patient age, deeper dermal involvement, ovoid\u2010to\u2010spindled morphology, central pericytoid vasculature, myxoid stroma, moderate cellularity with low to moderate MIB1 expression, superficial ulceration, and focal S100 protein expression. Complete excision was performed with favorable follow\u2010up to date. This novel <jats:italic>VCL::ALK<\/jats:italic> fusion spindle (ovoid) cell tumor of the dermis is best considered as part of the recently emerged <jats:italic>RAS::MAP<\/jats:italic> tyrosine kinase fusion sarcomas.<\/jats:p>","DOI":"10.1111\/cup.14420","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T02:28:17Z","timestamp":1677464897000},"page":"405-409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cutaneous <i>VCL::ALK<\/i> fusion <scp>ovoid\u2010spindle<\/scp> cell neoplasm"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7469-8569","authenticated-orcid":false,"given":"Matthew","family":"Helm","sequence":"first","affiliation":[{"name":"Department of Dermatology Penn State Hershey Medical Center  Hershey Pennsylvania 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