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These cases may signify a specific need for newer ancillary diagnostic technologies, including in vivo reflectance confocal microscopy (RCM) and gene expression profiling (GEP), both of which are highly sensitive in the diagnosis of melanoma. We report four cases of clinically suspicious melanocytic lesions that lacked definitive malignant features on histopathology and that were aided by use of RCM and GEP. Three of the four cases showed concordance between RCM and GEP in the diagnosis of melanoma. In one case, RCM was suggestive of melanoma; on the other hand, GEP and histopathology supported a final diagnosis of compound Spitz nevus. These cases support the role of RCM as a novel, non\u2010invasive diagnostic tool to aid in the diagnosis of clinically suspicious melanocytic lesions with uncertain malignant potential, although RCM may have relatively lower accuracy for some atypical spitzoid lesions.<\/jats:p>","DOI":"10.1111\/cup.14422","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T03:15:49Z","timestamp":1679454949000},"page":"623-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Concordance of reflectance confocal microscopy and gene expression profiling for melanocytic lesions with uncertain malignant potential: A case series"],"prefix":"10.1111","volume":"50","author":[{"given":"Christian","family":"Gronbeck","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Connecticut Health Center  Farmington Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold","family":"Rabinovitz","sequence":"additional","affiliation":[{"name":"Skin and Cancer Associates  Plantation Florida USA"},{"name":"Dermatology Department Medical College of Georgia at Augusta University  Augusta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret Oliviero","family":"NP","sequence":"additional","affiliation":[{"name":"Skin and Cancer Associates  Plantation Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1844-8415","authenticated-orcid":false,"given":"Jane M.","family":"Grant\u2010Kels","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Connecticut Health Center  Farmington Connecticut USA"},{"name":"Department of Dermatology University of Florida College of Medicine  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13548"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.06.033"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22600"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2021.03.010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15669"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.02.067"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.Cd013190"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.03.066"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18722"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8091462"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14122836"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.Cd013191"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.1570"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2217\/pme\u20102020\u20100048"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.12.001"},{"key":"e_1_2_6_17_1","unstructured":"Castle Biosciences.Overview of difficult\u2010to\u2010diagnose melanocytic lesions. 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