{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T17:31:47Z","timestamp":1780680707404,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aleukemic leukemia cutis (ALC) is a rare condition that is characterized by leukemic cells in the skin before presenting in the peripheral blood or bone marrow. We report a case of a 43\u2010year\u2010old woman who underwent assessment for bilateral facial nodules arising 1\u2009month after COVID\u201019 infection. A punch biopsy specimen showed a malignant neoplasm primarily composed of immature blasts dissecting through the collagen in the dermis, concerning for myeloid sarcoma versus leukemia cutis. Bone marrow and blood specimens were negative for hematologic malignancy. The patient was appropriately treated with chemotherapy and is recovering well. This report highlights an interesting case of ALC following COVID\u201019 infection presenting as an isolated facial rash. Whether there is a true relationship between the patient's COVID\u201019 infection and her abrupt presentation of leukemia remains unclear, but we present this case regardless, in an effort to highlight a potentially unique association requiring further study.<\/jats:p>","DOI":"10.1111\/cup.14431","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T05:11:13Z","timestamp":1681794673000},"page":"606-610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A case of aleukemic leukemia cutis after <scp>COVID<\/scp>\u201019 infection presenting as facial rash"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7745-2270","authenticated-orcid":false,"given":"Nancy W.","family":"Shen","sequence":"first","affiliation":[{"name":"University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristielle Peres de","family":"Freitas","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Bacchi  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E.","family":"Bacchi","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Bacchi  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro A.","family":"Gru","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Virginia  Charlottesville Virginia USA"},{"name":"Department of Dermatology University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4065\/71.2.166"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050313X20919638"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.86a.18057"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000190"},{"key":"e_1_2_8_6_1","volume-title":"StatPearls","author":"Parsi M","year":"2022"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijdvl.IJDVL_355_18"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.14423\/SMJ.0000000000000634"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000531"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e318073cf70"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010017\u20100452\u20109"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2021\u20100612\u2010RA"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001316"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP9IS9KFSVWKGH"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750\u20101172\u20102\u201034"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.6092"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021013967"},{"issue":"1","key":"e_1_2_8_18_1","article-title":"A case of acute leukemia following remission of COVID\u201019 infection; an urge to search for a probable association","volume":"9","author":"Nekooghadam SM","year":"2021","journal-title":"Arch Acad Emerg Med"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T01:48:15Z","timestamp":1692236895000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.14431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,17]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/cup.14431"],"URL":"https:\/\/doi.org\/10.1111\/cup.14431","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,17]]},"assertion":[{"value":"2022-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}