{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:11:20Z","timestamp":1780567880161,"version":"3.54.1"},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Extragastrointestinal stromal tumors (EGISTs) carry the same morphological, immunohistochemical and molecular features as gastrointestinal stromal tumors (GISTs) and involve extragastrointestinal tract soft tissue. The majority of reported EGIST cases arise from intraabdominal, retroperitoneal, or pelvic soft tissue. A significant subset of such tumors originates from the gastrointestinal muscle layer, grows in an exophytic manner, then loses attachment to the gastrointestinal tract. Consequently, true EGISTs are exceedingly rare. Herein, we are reporting a case of a vulvar EGIST. A 77\u2010year\u2010old woman presented with a painless subcutaneous nodule on the right perineum. An excisional biopsy showed a fairly circumscribed bland spindle cell lesion in the dermis. The tumor cells were positive for CD117 and ANO1\/DOG\u20101 and negative for smooth muscle myosin, smooth muscle actin, STAT6, low\u2010 and high\u2010molecular\u2010weight cytokeratins, SOX10, MART\u20101, CD10, S\u2010100 protein, and estrogen and progesterone receptors. A diagnosis of EGIST was made and complete excision was recommended. Superficial\/subcutaneous EGISTs are extremely rare, and it is important for dermatopathologists to be aware of this entity as it can be misdiagnosed as more common spindle cell neoplasms, both benign and malignant, including but not limited to smooth muscle neoplasms (leiomyoma\/leiomyosarcoma), spindle cell melanoma, and sarcomatoid squamous cell carcinoma.<\/jats:p>","DOI":"10.1111\/cup.14432","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T03:26:21Z","timestamp":1682997981000},"page":"723-729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Primary vulvar extragastrointestinal stromal tumor in a 77\u2010year\u2010old woman"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1548-1439","authenticated-orcid":false,"given":"Nada","family":"Mohamed","sequence":"first","affiliation":[{"name":"Department of Pathology Texas A&amp;M College of Medicine\u2010Baylor Scott &amp; White Health  Temple Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Khan","sequence":"additional","affiliation":[{"name":"ProPath  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6281-0565","authenticated-orcid":false,"given":"Gregory","family":"Hosler","sequence":"additional","affiliation":[{"name":"ProPath  Dallas Texas USA"},{"name":"Department of Dermatology University of Texas Southwestern  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Tumminello","sequence":"additional","affiliation":[{"name":"ProPath  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Soft Tissue and Bone Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2020"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31822d63a7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000146010.92933.de"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5350.577"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079666"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010200407000\u201000007"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2015.02.017"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2015.05.006"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2009.064550"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPPCKGA2QGBJ1R"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20589"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i6.1845"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880099"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957\u2010020\u201001961\u20101"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2011.343"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1048\u2010891x.2004.014230.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.5858\/2004\u2010128\u20101442\u2010GSTPAA"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525\u20101438.2005.00269.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pgp.0000215291.22867.18"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525\u20101438.2007.00892.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.02.019"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31819c7fc1"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2010.08.007"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384\u2010010\u20101002\u2010x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e31823b52af"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v4.i4.118"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2018.04.006"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015398"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.4103\/njcp.njcp_139_19"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S284101"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102559.2000.00865.x"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181cf7fc1"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31828bb49d"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000920"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14215217"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.5858\/2006\u2010130\u20101466\u2010GSTROM"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010200305000\u201000006"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31820e5f7d"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182260752"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009199108"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr130"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.0256"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1159\/000052009"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100560.2008.01067.x"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31818acb1a"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S261823"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.51.2046"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.74.9705"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13569\u2010019\u20100112\u20107"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201009\u2010399725"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqaa046"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201018\u20101201"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T04:23:13Z","timestamp":1692246193000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.14432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":52,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/cup.14432"],"URL":"https:\/\/doi.org\/10.1111\/cup.14432","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"2022-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}