{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T08:28:03Z","timestamp":1747643283394,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T00:00:00Z","timestamp":1683417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pseudoxanthoma elasticum (PXE) is an autosomal recessive genetic disorder characterized by aberrant fragmentation and calcification of elastic fibers, leading to characteristic cutaneous, ophthalmic, and cardiovascular manifestations. PXE demonstrates significant phenotypic variability; involvement of the oral mucosa may be the only clue to the diagnosis. Reports on mucous membrane involvement in PXE are scarce. Here, we present a case of PXE\u2010like changes in the oral cavity. A 70\u2010year\u2010old male patient presented with a painless leukoplakic lesion on the soft palate. Biopsy revealed numerous degenerated fibers in the lamina propria. Verhoeff\u2010van Gieson and von Kossa staining confirmed their identity as calcified elastic fibers. A histopathological diagnosis of PXE\u2010like changes was made; the patient was referred to ophthalmology where angioid streaks were visualized fundoscopically. PXE\u2010like changes in the absence of the characteristic genetic mutation have also been reported with or without systemic manifestations. Furthermore, PXE\u2010like changes have been reported in up to 10% of oral biopsy specimens undertaken without clinical suspicion for PXE. Therefore, the significance of such changes in isolation is unclear. Clinicians and pathologists should be aware of the potential oral manifestations of PXE to facilitate prompt diagnosis and subspecialist referral.<\/jats:p>","DOI":"10.1111\/cup.14445","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T03:03:31Z","timestamp":1683515011000},"page":"730-733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pseudoxanthoma\u2010elasticum\u2010like changes on the soft palate"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9375-4466","authenticated-orcid":false,"given":"Maximillian A.","family":"Weigelt","sequence":"first","affiliation":[{"name":"Department of Pathology Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Franklin","sequence":"additional","affiliation":[{"name":"Department of Pathology Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepan","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Pathology Sharon Regional Medical Center  Sharon Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven D.","family":"Billings","sequence":"additional","affiliation":[{"name":"Department of Pathology Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shira","family":"Ronen","sequence":"additional","affiliation":[{"name":"Department of Pathology Cleveland Clinic Foundation  Cleveland Ohio 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