{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:13:16Z","timestamp":1785683596810,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>CD30 expression has been infrequently described in cutaneous B\u2010cell lymphomas (CBCLs). We examined CD30 expression in reactive lymphoid hyperplasia (RLH) and CBCL and correlated expression with clinicopathologic features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CD30 was examined in 82 CBCL patients and 10 RLH patients that had been evaluated in our cutaneous lymphoma clinics. The CBCL patients included: primary cutaneous follicle center lymphoma (PCFCL), Grade 1\/2 systemic\/nodal follicular lymphoma (SFL); primary cutaneous marginal zone lymphoma\/lymphoproliferative disorder (PCMZL\/LPD); systemic marginal zone lymphoma (SMZL); primary cutaneous diffuse large B\u2010cell lymphoma, leg type (PCDLBCL\u2010LT); and extracutaneous\/systemic diffuse large B\u2010cell lymphoma (eDLBCL). We scored CD30 expression for intensity and extent and related CD30 expression to age at first diagnosis, sex, site of biopsy, clinical appearance, extracutaneous involvement, multiple cutaneous lesions, B\u2010symptoms, lymphadenopathy, positive positron emission tomography\/computed tomography (PET\/CT), elevated lactate dehydrogenase (LDH), and positive bone marrow biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CD30 expression was identified in 35% of CBCL, ranging from few, weak, scattered cells to strong and diffuse expression. It was most common in PCFCL and was not expressed in PCDLBCL\u2010LT. Rare PCFCL expressed strong, diffuse CD30. Some cases of PCMZL\/LPD, SMZL, FL, and RLH showed scattered, strongly positive cells. CD30 expression in CBCL was associated with favorable clinical features: younger age, negative PET\/CT, and an LDH within normal limits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CD30 may be expressed in CBCL, possibly causing diagnostic confusion. CD30 expression was most commonly identified in PCFCL and is associated with favorable clinical features. In cases with strong and diffuse expression, CD30 could be a therapeutic target.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14473","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T01:12:03Z","timestamp":1686273123000},"page":"819-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>CD30<\/scp> expression in cutaneous B\u2010cell lymphomas"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4963-1968","authenticated-orcid":false,"given":"Olabisi","family":"Afolayan\u2010Oloye","sequence":"first","affiliation":[{"name":"Department of Pathology Beaumont Hospital  Royal Oak Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Michigan School of Public Health  Ann Arbor Michigan 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