{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:45Z","timestamp":1787014065306,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Myxopapillary ependymoma (MPE) is an uncommon variant of ependymoma, almost exclusively seen in conus medullaris or filum terminale. MPE can be diagnostically challenging, especially when arising extra\u2010axially. Here we report 5 cases of superficial soft tissue\/cutaneous MPE, identified across three tertiary institutions. All patients were female and three of them (3\/5, 60%) were children (median age 11\u2009years, range 6\u201358\u2009years). The tumors presented as slow\u2010growing masses of the sacrococcygeal subcutaneous soft tissues, occasionally identified after minor trauma and clinically favored to be pilonidal sinuses. Imaging showed no neuraxis connection. Macroscopically, tumors were well\u2010circumscribed, lobulated, and solid and microscopically they exhibited typical histopathology of MPE, at least focally. Two of the tumors (2\/5, 40%) showed predominantly solid or trabecular architecture with greater cellular pleomorphism, scattered giant cells, and increased mitotic activity. All tumors (5\/5, 100%) showed strong diffuse immunohistochemical expression of GFAP. One tumor clustered at the category \u201cependymoma, myxopapillary\u201d by methylome analysis. Two patients (2\/5, 40%) had local recurrence at 8 and 30\u2009months after the initial surgery. No patients developed metastases during the follow\u2010up period (median 60\u2009months, range 6\u2013116\u2009months). Since a subset of extra\u2010axial MPEs behaves more aggressively, timely and accurate diagnosis is of paramount importance.<\/jats:p>","DOI":"10.1111\/cup.14475","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T04:30:58Z","timestamp":1686803458000},"page":"20-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["When a dermatopathologist encounters the ultra\u2010rare: A case series of superficial soft tissue\/cutaneous myxopapillary ependymomas"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6769-6952","authenticated-orcid":false,"given":"Kyriakos","family":"Chatzopoulos","sequence":"first","affiliation":[{"name":"Department of Pathology Aristotle University  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3412-2914","authenticated-orcid":false,"given":"Prodromos","family":"Hytiroglou","sequence":"additional","affiliation":[{"name":"Department of Pathology Aristotle University  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory W.","family":"Charville","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angus M. S.","family":"Toland","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Martinez\u2010Lage","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Cimino","sequence":"additional","affiliation":[{"name":"Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke National Institute of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc K.","family":"Rosenblum","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9462-652X","authenticated-orcid":false,"given":"Konstantinos","family":"Linos","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"183","volume-title":"Central Nervous System Tumours","author":"Rosenblum MK","year":"2021"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noy118"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010019\u201002090\u20100"},{"key":"e_1_2_9_5_1","first-page":"985","volume-title":"Enzinger and Weiss's Soft Tissue Tumors","author":"Goldblum JR","year":"2019"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010022\u201002513\u20105"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010022\u201002404\u20109"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature26000"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896917748195"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2006.03.015"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010198809000\u201000003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103468(86)80653\u20104"},{"issue":"1","key":"e_1_2_9_13_1","first-page":"1","article-title":"Three gliomata of ependymal origin; two in the fourth ventricle, one subcutaneous over the coccyx","volume":"8","author":"Mallory FB","year":"1902","journal-title":"J Med Res"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103468(85)80121\u20104"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102559.1993.tb00143.x"},{"issue":"1","key":"e_1_2_9_16_1","first-page":"164","article-title":"Myxopapillary ependymoma with extensive sacral destruction: CT and MR findings","volume":"16","author":"Moelleken SM","year":"1992","journal-title":"J Comput Assist Tomogr"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900515)65:10%3C2353::aid-cncr2820651032%3E3.0.co;2-d"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.25259\/SNI_768_2020"},{"issue":"2","key":"e_1_2_9_19_1","first-page":"76","article-title":"Metastasising congenital subcutaneous sacrococcygeal ependymoma","volume":"29","author":"Gupta RK","year":"1992","journal-title":"Indian J Cancer"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/81.2.156"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlaa077"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381\u2010018\u20103805\u2010y"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12673"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1979.51.3.0383"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196604)19:4%3C585::aid-cncr2820190418%3E3.0.co;2-y"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12713"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12580"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/01913123.2017.1327910"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.09.088"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000002043"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25125"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjaa177"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102019\u2010231639"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjw121"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746\u20101596\u20103\u201040"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060\u2010004\u20103117\u20109"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2013.05.028"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750\u20103639.2009.00333.x"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201014\u20102650"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0000000000000106"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noac088"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12866"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1479\u2010666x(04)80100\u20108"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10281"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2020\u20100258\u2010RA"},{"key":"e_1_2_9_46_1","first-page":"451","volume-title":"WHO Classification of Tumours of Soft Tissue and Bone","author":"Tirabosco R","year":"2020"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010015\u20100618\u20100"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10040108"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10183"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T03:29:12Z","timestamp":1703561352000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.14475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,15]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/cup.14475"],"URL":"https:\/\/doi.org\/10.1111\/cup.14475","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,15]]},"assertion":[{"value":"2022-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}