{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T01:30:55Z","timestamp":1746235855538},"reference-count":52,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:00:00Z","timestamp":1688515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The conventionally understood pathogenesis of agminated Spitz nevi includes a mosaic <jats:italic>HRAS<\/jats:italic> mutation followed by copy number gains in 11p. However, we have recently observed agminated presentations of fusion\u2010driven melanocytic neoplasms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrieved cases from our database of benign fusion\u2010induced melanocytic neoplasms with an agminated presentation. Both the primary lesion and the secondary lesion were sequenced. <jats:italic>TERT<\/jats:italic>\u2010promoter mutational testing and the melanoma fluorescence in situ hybridization assay were also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three cases were included. Two had a <jats:italic>PRKCA<\/jats:italic> fusion (partners <jats:italic>ATP2B4<\/jats:italic> and <jats:italic>MPZL1<\/jats:italic>) and one had a <jats:italic>ZCCHC8::ROS1<\/jats:italic> fusion. None of the cases met morphologic or molecular criteria for malignancy. There was no evidence of tumor progression in secondary lesions. The same fusion was identified in the primary and secondary lesions. None of the patients developed evidence of nodal or systemic metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We present accumulating evidence that fusion\u2010driven melanocytic neoplasms can present with an agminated presentation. The differential diagnosis of an agminated presentation versus a locally recurrent or potentially locally metastatic tumor is critical, and accurate diagnosis has significant prognostic and therapeutic consequences for the patient. As with <jats:italic>HRAS<\/jats:italic> mutations, fusion\u2010driven melanocytic tumors may have an agminated presentation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14482","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T02:57:50Z","timestamp":1688612270000},"page":"913-921","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Agminated presentation of fusion\u2010driven melanocytic neoplasms"],"prefix":"10.1111","volume":"50","author":[{"given":"M\u00f3nica","family":"Fumero\u2010Vel\u00e1zquez","sequence":"first","affiliation":[{"name":"Department of Dermatology Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hagstrom","sequence":"additional","affiliation":[{"name":"Department of Dermatology Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soneet","family":"Dhillon","sequence":"additional","affiliation":[{"name":"Department of Dermatology Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shantel","family":"Olivares","sequence":"additional","affiliation":[{"name":"Department of Dermatology Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence J.","family":"Jennings","sequence":"additional","affiliation":[{"name":"Division of Molecular Pathology, Department of Pathology Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Dittman","sequence":"additional","affiliation":[{"name":"Division of Molecular Pathology, Department of Pathology Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madina","family":"Sukhanova","sequence":"additional","affiliation":[{"name":"Division of Molecular Pathology, Department of Pathology Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoleta C.","family":"Arva","sequence":"additional","affiliation":[{"name":"Department of Pathology Ann &amp; Robert H. 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