{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:57:39Z","timestamp":1747184259754,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T00:00:00Z","timestamp":1694304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007812","name":"University of Washington","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007812","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cutaneous graft versus host disease (cGVHD) has substantial clinical and histopathologic overlap with erythema multiforme (EM), Stevens\u2013Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). This overlap can make it difficult to distinguish these disorders in patients who have received hematopoietic transplants. We sought to evaluate the utility of Dp I\/II immunohistochemical stain in differentiating EM\/SJS\/TEN and cGVHD in a large cohort. Skin biopsy specimens from patients with cGVHD (<jats:italic>n<\/jats:italic>\u2009=\u200958) and EM\/SJS\/TEN (<jats:italic>n<\/jats:italic>\u2009=\u200960) were evaluated for Dp I\/II expression by immunohistochemistry. We found a statistically significant difference in Dp I\/II staining between cGVHD (all grades) and EM\/SJS\/TEN (mean scores 1.62 and 2.14, respectively; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.005), as well as between Grades 2\u2009+\u20093 cGVHD and EM\/SJS\/TEN (mean scores 2.26 and 1.62, respectively; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.005), while we did not find a significant difference between Grade 4 cGVHD and EM\/SJS\/TEN (mean scores 1.69 and 1.62, respectively; <jats:italic>p<\/jats:italic>\u2009=\u20090.71). Dp I\/II immunostain may be useful for differentiating EM\/SJS\/TEN from Grade 2 and Grade 3 cGVHD, especially in clinically ambiguous cases without extracutaneous GVHD.<\/jats:p>","DOI":"10.1111\/cup.14513","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T03:34:40Z","timestamp":1694403280000},"page":"76-82","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Desmoplakin I\/<scp>II<\/scp> immunohistochemical staining may be a helpful tool in differentiating cutaneous graft versus host disease from the erythema multiforme, Stevens\u2013Johnson syndrome, and toxic epidermal necrolysis spectrum disorders"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0493-7410","authenticated-orcid":false,"given":"Trent","family":"Irwin","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia C. S.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington USA"},{"name":"Clinical Research Division Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michi M.","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington USA"},{"name":"Division of Dermatology, Department of Medicine University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,10]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1111\/j.1399-3062.2012.00746.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1097\/BCR.0000000000000040"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1084\/jem.181.1.169"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1046\/j.1523-1747.1998.00328.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1111\/j.1365-2133.2005.06671.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1111\/1523-1747.ep12338566"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1111\/ajd.12162"},{"issue":"10","key":"e_1_2_8_9_1","first-page":"1337","article-title":"Autoantibodies against desmoplakin I and II in patients with Stevens\u2010Johnson syndrome and toxic epidermal necrolysis","volume":"43","author":"Lee JB","year":"2005","journal-title":"Korean J Dermatol"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1097\/DAD.0000000000001545"},{"issue":"4","key":"e_1_2_8_11_1","first-page":"367","article-title":"Histopathology of graft\u2010vs.\u2010host reaction (GvHR) in human recipients of marrow from HL\u2010A\u2010matched sibling donors","volume":"6","author":"Lerner KG","year":"1974","journal-title":"Transplant Proc"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.1007\/s40257-018-0391-4"},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_1","DOI":"10.1016\/j.jaad.2014.01.480"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_1","DOI":"10.1007\/s40257-017-0306-9"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_1","DOI":"10.1016\/j.jpeds.2016.02.037"},{"doi-asserted-by":"publisher","key":"e_1_2_8_16_1","DOI":"10.1007\/s00277-003-0643-z"},{"doi-asserted-by":"publisher","key":"e_1_2_8_17_1","DOI":"10.5070\/D3209023901"},{"doi-asserted-by":"publisher","key":"e_1_2_8_18_1","DOI":"10.1177\/106002809202600109"},{"doi-asserted-by":"publisher","key":"e_1_2_8_19_1","DOI":"10.1111\/j.1346-8138.1997.tb02308.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_20_1","DOI":"10.1002\/pbc.21493"},{"doi-asserted-by":"publisher","key":"e_1_2_8_21_1","DOI":"10.1038\/sj.bmt.1703624"},{"issue":"2","key":"e_1_2_8_22_1","first-page":"158","article-title":"Toxic epidermal necrolysis following bone marrow transplantation","volume":"34","author":"Friedman HZ","year":"1984","journal-title":"Cutis"},{"doi-asserted-by":"publisher","key":"e_1_2_8_23_1","DOI":"10.1016\/0190-9622(90)70307-4"},{"doi-asserted-by":"publisher","key":"e_1_2_8_24_1","DOI":"10.1038\/sj.bmt.1705572"},{"doi-asserted-by":"publisher","key":"e_1_2_8_25_1","DOI":"10.1016\/j.burns.2017.09.015"},{"doi-asserted-by":"publisher","key":"e_1_2_8_26_1","DOI":"10.1684\/ejd.2010.1150"},{"doi-asserted-by":"publisher","key":"e_1_2_8_27_1","DOI":"10.1111\/j.1365-2230.2005.01736.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_28_1","DOI":"10.1111\/j.1468-3083.1998.tb00774.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_29_1","DOI":"10.1111\/j.1365-2133.1994.tb04985.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_30_1","DOI":"10.1016\/j.jaad.2003.11.051"},{"doi-asserted-by":"publisher","key":"e_1_2_8_31_1","DOI":"10.1056\/NEJM199012203232503"},{"doi-asserted-by":"publisher","key":"e_1_2_8_32_1","DOI":"10.1111\/j.1365-2257.2005.00699.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_33_1","DOI":"10.1111\/j.1529-8019.2011.01397.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T08:29:40Z","timestamp":1703579380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.14513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,10]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/cup.14513"],"URL":"https:\/\/doi.org\/10.1111\/cup.14513","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"type":"print","value":"0303-6987"},{"type":"electronic","value":"1600-0560"}],"subject":[],"published":{"date-parts":[[2023,9,10]]},"assertion":[{"value":"2022-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}