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While the clinical presentation of cutaneous malakoplakia is variable, the histopathologic features are quite distinct and include sheets of closely packed dermal histiocytes with foamy\u2010appearing cytoplasm and Michaelis\u2013Gutmann bodies that are positive with certain immunohistochemical stains. While the exact pathogenesis of malakoplakia is unknown, it has been associated with certain bacterial infections. Treatment generally involves a combination of surgery and antimicrobial agents and\/or modulation of immunosuppressant therapy if appropriate. Herein, the authors report a unique case of cutaneous malakoplakia arising in a patient on chronic immunosuppressive therapy for the management of pyoderma gangrenosum.<\/jats:p>","DOI":"10.1111\/cup.14519","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:31:14Z","timestamp":1692873074000},"page":"942-946","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cutaneous malakoplakia arising on the ankle of a patient with pyoderma gangrenosum"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1119-8596","authenticated-orcid":false,"given":"Carli P.","family":"Whittington","sequence":"first","affiliation":[{"name":"Department of Pathology University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Dermatology University of Michigan  Ann Arbor Michigan USA"},{"name":"Departments of Pathology and Dermatology Indiana University  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmine S.","family":"Saleh","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Dermatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Schadler","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole","family":"Bitar","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Dermatology Tulane University  New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Michigan  Ann Arbor Michigan 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