{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:15:26Z","timestamp":1792268126249,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:00:00Z","timestamp":1693353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcriptional repressor GATA binding 1 (TRPS1) is a transcription factor recently shown to play a role in the development of breast and liver cancer. Here, we evaluate TRPS1 immunoexpression in normal skin tissues and various cutaneous tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>TRPS1 immunohistochemistry was performed in 109 cases of primary cutaneous tumors and 19 cases of metastatic carcinomas. TRPS1 expression was also evaluated in the normal skin tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The normal epidermis was TRPS1\u2212. In contrast, the eccrine apparatus, epithelial compartment of the hair follicles, hair papilla, sebaceous glands, and anogenital mammary\u2010like glands were TRPS1+. In primary cutaneous tumors, TRPS1 positivity varied in poroma (2\/3), nodular hidradenoma (4\/5), spiradenoma (4\/4), cutaneous mixed tumor (5\/5), trichilemmal cyst (7\/8), proliferating trichilemmal tumor (1\/3), pilomatricoma (9\/9), sebaceoma (2\/5), extramammary Paget disease (13\/13), sebaceous carcinoma (2\/2), actinic keratosis (3\/10), Bowen disease (7\/12), and squamous cell carcinoma (1\/5) cases. All cases of seborrheic keratosis, basal cell carcinoma, Merkel cell carcinoma, and malignant melanoma were TRPS1\u2212. All metastatic breast carcinoma cases (8\/8) were highly positive for TRPS1, while all but one of the other metastatic tumor cases were TRPS1\u2212.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TRPS1 immunoexpression was observed in several skin appendages and cutaneous tumors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14523","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T05:55:55Z","timestamp":1693461355000},"page":"1006-1013","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Transcriptional repressor <scp>GATA<\/scp> binding 1 (<scp>TRPS1<\/scp>) immunoexpression in normal skin tissues and various cutaneous tumors"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5504-9221","authenticated-orcid":false,"given":"Kohei","family":"Taniguchi","sequence":"first","affiliation":[{"name":"Department of Pathology 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