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Giant PMs are a rare histopathological variant, according to the World Health Organization, which are defined by a size greater than 4\u2009cm and are reported to show upregulation of yes\u2010associated protein compared to PMs of typical 1\u20133\u2009cm size. We describe the case of a 67\u2010year\u2010old man with an 8\u2009cm giant PM involving his temporal scalp, whose PM we characterized by 10X spatial gene expression analysis. This revealed five total transcriptomic clusters, including four distinct clusters within the giant PM, each with a unique transcriptional pattern of hair follicle\u2010related factors, keratin gene expression, and beta\u2010catenin pathway activity.<\/jats:p>","DOI":"10.1111\/cup.14524","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T05:38:59Z","timestamp":1693460339000},"page":"963-970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Spatial transcriptomics of a giant pilomatricoma"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6339-0419","authenticated-orcid":false,"given":"Apoorva T.","family":"Patil","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel 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