{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:22:36Z","timestamp":1780446156618,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During the coronavirus disease 2019 (COVID\u201019) pandemic, COVID\u201019 vaccines were administered worldwide. A number of skin reactions, including primary cutaneous T\u2010cell lymphoproliferative disorders (LPDs) were reported following COVID\u201019 vaccination. We report a case of primary cutaneous marginal zone lymphoproliferative disorder (PCMZLPD) secondary to COVID\u201019 vaccination. A 57\u2010year\u2010old man presented with an erythematous nodule on his left arm at the site of vaccine inoculation following his first dose of the Moderna (mRNA\u20101273) vaccine a few weeks prior. The nodule continued to progress in size after the second dose. A skin biopsy specimen of the nodule showed a diffuse dermal infiltrate of small to medium\u2010sized lymphocytes with plasma cells and histiocytes. The infiltrate was composed of CD3<jats:sup>+<\/jats:sup> T cells with CD20<jats:sup>+<\/jats:sup> and CD79a<jats:sup>+<\/jats:sup> B cells. The neoplastic B cells reacted with BCL\u20102 and were negative for BCL\u20106 and CD10. Kappa light chain restriction was identified by in situ hybridization. Gene rearrangement studies revealed kappa light chain monoclonality, confirming the diagnosis of PCMZLPD. The temporal association with the Moderna vaccination and the occurrence of the lesion at the inoculation site indicate a COVID\u201019 vaccination\u2010induced PCMZLPD. This is one of the rare cases of PCMZLPD following COVID\u201019 vaccination.<\/jats:p>","DOI":"10.1111\/cup.14550","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T07:09:47Z","timestamp":1701241787000},"page":"193-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Primary cutaneous marginal zone lymphoproliferative disorder following <scp>COVID<\/scp>\u201019 vaccination"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0454-2635","authenticated-orcid":false,"given":"Carla","family":"Stephan","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Weill Cornell Medicine\/New York\u2010Presbyterian  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Barone","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Weill Cornell Medicine\/New York\u2010Presbyterian  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Weill Cornell Medicine\/New York\u2010Presbyterian  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linglei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pathology\u2010Laboratory Medicine University of Virginia  Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.03.092"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.2383"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18806"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.963393"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.6396"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201011\u2010881268"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015851"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17736"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18246"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16296"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17744"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2022.08.006"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2035389"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.106"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010020\u201004336\u20104"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.04.036"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.12.021"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.11.009"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T08:17:29Z","timestamp":1706775449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.14550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,28]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/cup.14550"],"URL":"https:\/\/doi.org\/10.1111\/cup.14550","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,28]]},"assertion":[{"value":"2023-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}