{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:42:41Z","timestamp":1790678561106,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 52\u2010year\u2010old female presented with labial ulcer of 4\u2010month duration. Examination showed 1\u2009cm\u2009\u00d7\u20091\u2009cm single superficial ulcer in the right labium majus. Excision was done, and histopathologic examination revealed surface ulceration and dermal invasion by epithelial neoplasm formed of biphasic proliferation of squamoid and gland\u2010forming cells. Immunohistochemical staining with p63 showed nuclear staining of the squamoid nests and was negative in areas with glandular differentiation, while epithelial membrane antigen and carcinoembryonic antigen highlighted the glandular elements. The case was diagnosed as primary cutaneous adenosquamous carcinoma (ASC). ASC is an uncommon malignant cutaneous neoplasm that is more aggressive than conventional squamous cell carcinoma. There are a few reports of ASC that presented as an erythematous papule or plaque with a preference for the head, neck, or upper extremities. We report a novel case of vulval ASC presented as a superficial ulcer, which is considered a unique site, and its clinical presentation.<\/jats:p>","DOI":"10.1111\/cup.14587","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:53:50Z","timestamp":1705452830000},"page":"329-331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adenosquamous carcinoma of the vulva: Rare tumor with unusual clinical presentation"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4147-1397","authenticated-orcid":false,"given":"Hala M.","family":"El Hanbuli","sequence":"first","affiliation":[{"name":"Pathology Department, Faculty of Medicine Fayoum University  Faiyum Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa A. Abou","family":"Sarie","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculty of Medicine Fayoum University  Faiyum Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gehan Azoz","family":"Ibrahium","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculty of Medicine Fayoum University  Faiyum Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Al\u2010Amaragy","sequence":"additional","affiliation":[{"name":"El\u2010khaleya Labs for Histopathology  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Elsonbaty","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, Faculty of Medicine Assiut University  Asyut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303\u20106987.2006.00516_1.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.218"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1985.01660060089028"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100560.1991.tb01228.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100560.1991.tb00602.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102559.1997.d01\u2010593.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000599"},{"key":"e_1_2_7_9_1","first-page":"42","volume-title":"WHO Classification of Skin Tumors","author":"Murphy GF","year":"2018"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000147397.08853.6f"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050313X18801217"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T08:53:51Z","timestamp":1712566431000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.14587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,16]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/cup.14587"],"URL":"https:\/\/doi.org\/10.1111\/cup.14587","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,16]]},"assertion":[{"value":"2023-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}