{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:35:23Z","timestamp":1790573723566,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In the 1980s, immunohistochemistry and clonality analyses became instrumental in the recognition and definition of new types of cutaneous T\u2010cell lymphoma (CTCL) and cutaneous B\u2010cell lymphoma (CBCL) and the development of new classifications. By accepting loss of pan\u2010T\u2010cell antigens and clonal T\u2010cell receptor gene rearrangements as important criteria to differentiate between benign and malignant T\u2010cell proliferations, and monotypic immunoglobulin light\u2010chain expression and clonal immunoglobulin gene rearrangements as crucial criteria to distinguish between benign and malignant B\u2010cell proliferations, many cases, until then diagnosed as cutaneous lymphoid hyperplasia or pseudolymphoma, were reclassified as primary cutaneous CD4+ small\/medium T\u2010cell lymphoma (PCSM\u2010TCL) or primary cutaneous marginal zone lymphoma (PCMZL), respectively. However, in recent years there is growing awareness that neither these immunohistochemical criteria nor demonstration of T\u2010cell or B\u2010cell clonality is specific for malignant lymphomas. In addition, many studies have reported that these low\u2010grade malignant CTCL and CBCL have an indolent clinical behavior and an excellent prognosis with disease\u2010specific survival rates of or close to 100%. As a result, recent classifications have downgraded several low\u2010grade malignant cutaneous lymphomas to lymphoproliferative disorder (LPD). Both the 5th edition of the WHO classification (2022) and the 2022 International Consensus Classification (ICC) of mature lymphoid neoplasms reclassified PCSM\u2010TCL as primary cutaneous CD4+ small\/medium T\u2010cell LPD and primary cutaneous acral CD8+ T\u2010cell lymphoma as primary cutaneous acral CD8+ T cell LPD. While the 2022 ICC introduced the term \u201cprimary cutaneous marginal zone LPD,\u201d in the 5th edition of the WHO classification PCMZL is maintained. In this review we describe the background and rationale of the continually changing terminology of these conditions and discuss the clinical consequences of downgrading malignant lymphomas to LPDs.<\/jats:p>","DOI":"10.1111\/cup.14609","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:08:54Z","timestamp":1710806934000},"page":"468-476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cutaneous lymphoproliferative disorders: Back to the future"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4561-7616","authenticated-orcid":false,"given":"Rein","family":"Willemze","sequence":"first","affiliation":[{"name":"Department of Dermatology Leiden University Medical Center  Leiden The 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