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A 79\u2010year\u2010old man presented with a red\u2013purple plaque on the scalp. A skin biopsy revealed epithelioid cell proliferation, admixed with numerous MGCs, and background hemorrhage. Vascular spaces were focally present and lined by atypical endothelial cells, including MGCs. Immunohistochemically, tumor cells, including MGCs, were positive for CD31, D2\u201040, and ERG. The patient received radiation therapy and chemotherapy, after which a follow\u2010up CT scan revealed symptomless pneumothorax and pulmonary metastases. The patient received palliative partial lung resection, and the specimen revealed histopathological and immunohistochemical features similar to the primary cutaneous lesion. Our report expands the morphologic spectrum of cutaneous epithelioid angiosarcoma. Cutaneous angiosarcoma is an aggressive neoplasm; thus, awareness of this rare manifestation is important.<\/jats:p>","DOI":"10.1111\/cup.14614","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T08:24:46Z","timestamp":1711355086000},"page":"430-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Numerous multinucleated giant cells in cutaneous epithelioid angiosarcoma and pulmonary metastasis: A unique observation with potential diagnostic pitfalls"],"prefix":"10.1111","volume":"51","author":[{"given":"Yushi","family":"Kanatani","sequence":"first","affiliation":[{"name":"Department of Dermatology Nara Medical University School of Medicine  Kashihara 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