{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:05:05Z","timestamp":1789387505708,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis is an inflammatory skin disease driven by upregulation of cytokines in the Th17 pathway, including interleukin\u201036 (IL\u201036). Previous studies have highlighted the utility of IL\u201036 immunostaining for psoriasis compared to spongiotic dermatitis and other psoriasiform dermatoses; however, no study has examined the role of IL\u201036 staining in distinguishing psoriasis from pityriasis rosea (PR) and pityriasis lichenoides (PL), known histologic mimickers of psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared the immunostaining pattern of IL\u201036 for 21 PR cases, 22 PL cases, and 10 psoriasis cases. We graded the immunostaining as 0, negative; 1, focal weak; 2, diffuse weak; 3, focal, strong; or 4, diffuse strong. We further categorized stains as negative (0\u20132 score) or positive (3\u20134 score) and utilized Fisher's exact test to compare the immunostaining pattern of these entities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All psoriasis specimens were positive for IL\u201036, whereas all PR specimens were negative (<jats:italic>p<\/jats:italic>\u2009=\u20090.00000002). Twenty PL specimens were negative (<jats:italic>p<\/jats:italic>\u2009=\u20090.000001). Nine of 10 pityriasis lichenoides et varioliformis acuta cases were negative (<jats:italic>p<\/jats:italic>\u2009=\u20090.00012), and 11 of 12 cases of pityriasis lichenoides chronica were negative (<jats:italic>p<\/jats:italic>\u2009=\u20090.00003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings highlight the potential role of IL\u201036 immunostaining in distinguishing psoriasis from other psoriasiform dermatoses, including PR and PL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14633","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T05:40:06Z","timestamp":1714542006000},"page":"618-623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Utility of IL\u201036 immunostaining in distinguishing psoriasis from pityriasis rosea and pityriasis lichenoides"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8198-4536","authenticated-orcid":false,"given":"Marina Kristy","family":"Ibraheim","sequence":"first","affiliation":[{"name":"Department of Dermatology Loma Linda University Health  Loma Linda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3973-5314","authenticated-orcid":false,"given":"Jeffrey P.","family":"North","sequence":"additional","affiliation":[{"name":"Department of Pathology and Dermatology University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133318"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122526"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8065147"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010021\u201000677\u20108"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201045626\u2010w"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.08.023"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.14115"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2016.28.4.451"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.532"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20102265"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.14105"},{"issue":"5","key":"e_1_2_8_13_1","first-page":"43","article-title":"Serum 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