{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:57:58Z","timestamp":1747184278149,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mycosis fungoides (MF) represents the most common type of primary cutaneous T\u2010cell lymphoma. Recognition of MF variants with divergent immunophenotypes is important for accurate diagnosis and appropriate management, as they can be confused with other lymphoma subtypes. We present a case of a 49\u2010year\u2010old male previously diagnosed with a cutaneous lymphoproliferative disorder with an unusual NK\/T\u2010cell phenotype. He presented with a 10\u2010year history of pelvic girdle rash involving the right hip and upper thigh. The lesions were characterized as atrophic patches concentrated in sun\u2010protected areas and involving 10% of the body surface area. Shave biopsies revealed an atypical epidermotropic infiltrate composed of hyperchromatic small to medium\u2010sized lymphocytes with perinuclear halos and \u201ctagging\u201d along the dermal\u2013epidermal junction. The immunophenotype was unusual in that the neoplastic lymphocytes showed complete loss of pan T\u2010cell antigens along with expression of CD56, cytotoxic markers, and weak CD20. All other B\u2010cell markers were negative. The combination of clinical findings, in addition to the histopathologic and immunophenotypic profile, were diagnostic of null T\u2010cell phenotype MF with aberrant expression of CD56 and CD20. Null T\u2010cell phenotype MF is very uncommon, can be diagnostically challenging, and can mislead the diagnosis of aggressive lymphoma subtypes.<\/jats:p>","DOI":"10.1111\/cup.14643","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T06:54:05Z","timestamp":1715324045000},"page":"614-617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Null T\u2010cell phenotype mycosis fungoides with aberrant CD20 and CD56 expression: A diagnostic dilemma"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-3540","authenticated-orcid":false,"given":"Brenna M.","family":"Aran","sequence":"first","affiliation":[{"name":"University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Burton","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Virginia  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Whitney A.","family":"High","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Colorado  Denver Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro A.","family":"Gru","sequence":"additional","affiliation":[{"name":"Department of Dermatology Columbia University  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1016\/j.clindermatol.2019.01.004"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1016\/j.anndiagpath.2020.151546"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1016\/j.path.2014.02.003"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1016\/j.jaad.2005.01.133"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.1111\/bjd.13563"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1111\/j.1365\u20102133.1993.tb03328.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_1","DOI":"10.1097\/DAD.0000000000000493"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_1","DOI":"10.1097\/DAD.0b013e31828cf3d3"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_1","DOI":"10.1111\/j.1365\u20102133.2008.08761.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_1","DOI":"10.1016\/j.jaad.2006.01.020"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_1","DOI":"10.4132\/KoreanJPathol.2014.48.5.390"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_1","DOI":"10.1097\/DAD.0b013e31818ffbe8"},{"doi-asserted-by":"publisher","key":"e_1_2_6_14_1","DOI":"10.1136\/jcp.2006.042135"},{"doi-asserted-by":"publisher","key":"e_1_2_6_15_1","DOI":"10.3390\/cancers13061414"},{"doi-asserted-by":"publisher","key":"e_1_2_6_16_1","DOI":"10.18632\/oncotarget.4146"},{"doi-asserted-by":"publisher","key":"e_1_2_6_17_1","DOI":"10.1111\/cup.12299"},{"doi-asserted-by":"publisher","key":"e_1_2_6_18_1","DOI":"10.12688\/f1000research.12449.1"},{"doi-asserted-by":"publisher","key":"e_1_2_6_19_1","DOI":"10.1016\/s0190\u20109622(99)70063\u20100"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T01:17:50Z","timestamp":1726622270000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.14643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,9]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/cup.14643"],"URL":"https:\/\/doi.org\/10.1111\/cup.14643","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"type":"print","value":"0303-6987"},{"type":"electronic","value":"1600-0560"}],"subject":[],"published":{"date-parts":[[2024,5,9]]},"assertion":[{"value":"2024-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}