{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:57:59Z","timestamp":1747184279268,"version":"3.40.5"},"reference-count":9,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The potential adverse health effects of antiperspirant use are of interest to patients, primary care providers, dermatologists, and pathologists. In rare instances, antiperspirants containing aluminum\u2013zirconium complexes have been associated with granulomatous dermatoses despite being deemed non\u2010sensitizing in experiments. In this case study, we present a detailed examination of an axillary granuloma in a 28\u2010year\u2010old female who had been using an aluminum\u2013zirconium\u2010based antiperspirant for several years and presented with a left axillary nodule that was excised and analyzed using scanning electron microscopy with energy\u2010dispersive x\u2010ray analysis (SEM\/EDXA). Histopathological examination revealed a foreign body\u2010type reaction with amphophilic granular material within giant cells that corresponded to collocated zirconium and aluminum on SEM\/EDXA elemental maps. Our case adds to the limited reports of axillary granulomas related to aluminum\u2013zirconium complexes. It illustrates the histopathological appearance and in situ distribution of the aluminum\u2013zirconium complexes, supporting the formation of foreign body\u2010type granulomas. Additionally, our case study illustrates the potential role of these compounds in such reactions and aims to increase awareness among pathologists and clinicians.<\/jats:p>","DOI":"10.1111\/cup.14662","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T05:39:58Z","timestamp":1719380398000},"page":"742-745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antiperspirant\u2010related zirconium and aluminum\u2010containing granulomas; histopathology and in situ chemical analysis"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8436-990X","authenticated-orcid":false,"given":"Jeffrey A.","family":"Sanford","sequence":"first","affiliation":[{"name":"Department of Pathology Walter Reed National Military Medical Center  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Candelaria\u2010Santiago","sequence":"additional","affiliation":[{"name":"Department of Pathology Carl R. Darnall Army Medical Center  Fort Hood Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic M.","family":"Forte","sequence":"additional","affiliation":[{"name":"Department of Surgery Carl R. Darnall Army Medical Center  Fort Hood Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian A.","family":"Curcio","sequence":"additional","affiliation":[{"name":"Soft Tissue Pathology The Joint Pathology Center  Silver Spring Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill I.","family":"Allbritton","sequence":"additional","affiliation":[{"name":"Dermatopathology The Joint Pathology Center  Silver Spring Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacy L.","family":"Strausborger","sequence":"additional","affiliation":[{"name":"Environmental Pathology The Joint Pathology Center  Silver Spring Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Lewin\u2010Smith","sequence":"additional","affiliation":[{"name":"Environmental Pathology The Joint Pathology Center  Silver Spring Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"US Department of Health and Human Services.Antiperspirant drug products for over\u2010the\u2010counter human use. 21 CFR \u00a7350.2003Accessed June 28 2023.https:\/\/www.ecfr.gov\/current\/title-21\/chapter-I\/subchapter-D\/part-350"},{"issue":"3","key":"e_1_2_7_3_1","first-page":"38","article-title":"Antiperspirant and deodorant allergy: diagnosis and management","volume":"1","author":"Zirwas MJ","year":"2008","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.2011.01889.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.1605"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190\u20109622(93)70122\u2010a"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190\u20109622(97)70159\u20102"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523\u20101747.ep12496465"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467\u20102494.2001.00092.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c22771"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T12:09:17Z","timestamp":1731845357000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.14662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,25]]},"references-count":9,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/cup.14662"],"URL":"https:\/\/doi.org\/10.1111\/cup.14662","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"type":"print","value":"0303-6987"},{"type":"electronic","value":"1600-0560"}],"subject":[],"published":{"date-parts":[[2024,6,25]]},"assertion":[{"value":"2023-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}