{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:09:13Z","timestamp":1790287753109,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nail squamous cell carcinoma (NSCC) is the most frequent ungual malignant tumor, but its incidence remains low. The histopathological description is sparse. We aim to characterize NSCC histopathological aspects, search for a correlation with clinical subtypes, and investigate immunohistochemistry expression of p16, p53, and Ki67.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study collected NSCC diagnosed in our dermatology department between 2007 and 2021. The histopathological features were correlated with the clinical signs and immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 48 patients were included, and immunohistochemistry was available for 36 of them. Two histopathological patterns became prominent: a blue\u2010basaloid type characterized by koilocytosis (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and a pink\u2010keratinizing type. Mean ages were similar when comparing basaloid and periungual versus keratinizing and subungual (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). p16 was positive in 31 of 36 cases: 18 basaloid and 13 keratinizing (<jats:italic>p<\/jats:italic>\u2009=\u20090.167). p53 and Ki67 were all abnormal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study described two histopathological NSCC subtypes and associated them with the two clinical subtypes: the blue\u2010basaloid type, HPV\u2010induced, in situ, of periungual localization in younger males; and the pink\u2010keratinizing type, non\u2010HPV\u2010induced, invasive, of subungual site, in elderly. Immunohistochemistry was not contributing on its own, but p16 positivity associated with basaloid histopathological profile helps support HPV etiology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14666","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T05:05:57Z","timestamp":1719032757000},"page":"714-723","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Squamous cell carcinoma of the nail apparatus: Histopathology and immunohistochemistry correlation study"],"prefix":"10.1111","volume":"51","author":[{"given":"Florine","family":"Moulart","sequence":"first","affiliation":[{"name":"Dermatology Department Saint\u2010Pierre University Hospital\u2014Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Olemans","sequence":"additional","affiliation":[{"name":"Dermatology Department Saint\u2010Pierre University Hospital  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"de Saint Aubain","sequence":"additional","affiliation":[{"name":"Anatomy Pathology Department University Hospital of Brussels\u2014Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Richert","sequence":"additional","affiliation":[{"name":"Dermatology Department Saint\u2010Pierre and Brugmann University Hospitals\u2014Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josette","family":"Andr\u00e9","sequence":"additional","affiliation":[{"name":"Dermatology Department Saint\u2010Pierre and Brugmann University Hospitals\u2014Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.02.008"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.0803a17"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2023.03.006"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2006.07744.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.02.057"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001805"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.03.070"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.184"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190\u20109622(98)70331\u20107"},{"key":"e_1_2_11_11_1","unstructured":"GilmantC.Carcinomes \u00e9pidermo\u00efdes ungu\u00e9aux diagnostiqu\u00e9s en Belgique: Association \u00e0 HPV et profil immunohistochimique de 23 cas. 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