{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:41:22Z","timestamp":1758818482749,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Circumscribed palmar hypokeratosis (CPH) is a localized disorder of epidermal keratinization that is presented as a well\u2010delimited, depressed, erythematous plaque on the palms or on the soles. It is histopathologically characterized by an abrupt thinning of the corneal epidermal layer. CPH is considered a benign condition, but a few cases with dysplastic changes\/carcinoma in situ in the hypokeratotic epidermis have been described. We report hereby a case of invasive squamous cell carcinoma developed within a plaque of CPH. The pathogenesis of the malignant changes in this disorder remains to be clarified. Clinicians should be aware of the potential for developing malignancy in CPH and carry out a closer follow\u2010up of this disorder.<\/jats:p>","DOI":"10.1111\/cup.14670","type":"journal-article","created":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T12:26:15Z","timestamp":1717849575000},"page":"732-734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Invasive squamous cell carcinoma within a plaque of circumscribed palmar hypokeratosis"],"prefix":"10.1111","volume":"51","author":[{"given":"Luis","family":"Araya","sequence":"first","affiliation":[{"name":"Department of Pathology Hospital Universitario de Fuenlabrada  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia","family":"Horcajada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de Fuenlabrada  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amalia","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitario de Fuenlabrada  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas M.","family":"Borbujo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de Fuenlabrada  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1805-961X","authenticated-orcid":false,"given":"Juan C.","family":"Tard\u00edo","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitario de Fuenlabrada  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,8]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1067\/mjd.2002.120466"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1159\/000264607"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.1016\/j.jdcr.2020.01.006"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1097\/DAD.0000000000002293"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.7759\/cureus.3440"},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_1","DOI":"10.1097\/01.dad.0000193825.90552.4e"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.1016\/j.jaad.2005.11.1081"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_1","DOI":"10.1016\/j.jaad.2007.02.035"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_1","DOI":"10.1684\/ejd.2013.1963"},{"doi-asserted-by":"publisher","key":"e_1_2_7_11_1","DOI":"10.1111\/bjd.15407"},{"doi-asserted-by":"publisher","key":"e_1_2_7_12_1","DOI":"10.1111\/j.1365\u20102133.2011.10245.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14670","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T12:09:09Z","timestamp":1731845349000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.14670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,8]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/cup.14670"],"URL":"https:\/\/doi.org\/10.1111\/cup.14670","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"type":"print","value":"0303-6987"},{"type":"electronic","value":"1600-0560"}],"subject":[],"published":{"date-parts":[[2024,6,8]]},"assertion":[{"value":"2023-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}