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In this report, we present an 81\u2010year\u2010old female with early\u2010stage MF who simultaneously progressed to tumor stage, large\u2010cell transformed (LCT) MF and developed a primary DLBCL in a lymph node (LN). She presented with a tumor on her leg and new lymphadenopathy in her right axilla. Skin biopsy of the tumor revealed infiltration of large atypical CD3<jats:sup>+<\/jats:sup>, CD4<jats:sup>+<\/jats:sup>, and CD30<jats:sup>+<\/jats:sup> cells, and a smaller portion of CD8<jats:sup>+<\/jats:sup> cells in the dermis, consistent with LCT MF. Biopsy of the axillary LN revealed diffuse sheets of CD20<jats:sup>+<\/jats:sup>, BCL\u20102<jats:sup>+<\/jats:sup>, c\u2010MYC<jats:sup>+<\/jats:sup>, and CD10<jats:sup>\u2212<\/jats:sup> cells, highly suggestive of double expressor DLBCL. High\u2010throughput sequencing revealed monoclonal T cells in the skin tumor and a monoclonal B\u2010cell population in the LN. The above findings led to simultaneous diagnoses of LCT MF and nodal double expressor DLBCL. Our case demonstrates the importance of performing a full pathological workup in cutaneous T\u2010cell lymphoma patients presenting with lymphadenopathy.<\/jats:p>","DOI":"10.1111\/cup.14673","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T09:29:13Z","timestamp":1720171753000},"page":"761-766","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Coexistence of large cell transformed mycosis fungoides and diffuse large B\u2010cell lymphoma in one patient"],"prefix":"10.1111","volume":"51","author":[{"given":"Thomas Z.","family":"Rohan","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayson","family":"Suriano","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Thomas Jefferson 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