{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T03:44:24Z","timestamp":1772509464625,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T00:00:00Z","timestamp":1720310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The underlying pathogenesis of pityriasis lichenoides et varioliformis acuta (PLEVA) remains unclear, although immunologic injury and viral etiology have been suggested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate and expand the immunophenotype of PLEVA and to search for possible viral pathogens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Formalin\u2010fixed, paraffin\u2010embedded specimens of 20 patients with PLEVA and 9 patients with common inflammatory dermatoses (ID) were studied for immunophenotyping and for human herpesvirus (HHV) 1 and 2, cytomegalovirus (CMV), HHV\u20108, parvovirus B19, and Epstein\u2013Barr virus (EBV) immunohistochemistry. The presence of HHV\u20106, HHV\u20107, and enteroviruses was assayed molecularly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The numbers of CD8<jats:sup>+<\/jats:sup> T cells and T\u2010cell intracellular antigen\u20101 (TIA\u20101)<jats:sup>+<\/jats:sup> cells were statistically significantly higher in PLEVA compared to the ID group. Immunohistochemistry for human HHV\u20101 and HHV\u20102, CMV and HHV\u20108, parvovirus B19, and in situ hybridization for EBV were all negative. There was molecular evidence for HHV\u20107 in only one PLEVA case (5%). Molecular studies for HHV\u20106 and enterovirus involvement were negative in all the PLEVA specimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The predominant T\u2010cell infiltrate in PLEVA is dominated by CD8<jats:sup>+<\/jats:sup> cells, and by increased numbers of TIA1<jats:sup>+<\/jats:sup> cells, which may indicate a cytotoxic T\u2010cell damage to the epidermis. 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