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This review summarizes the current literature on NGS\u2010based sequencing methods for the assessment of TCR clonality in the evaluation of atypical cutaneous lymphoid infiltrates and CTCL on behalf of the American Society of Dermatopathology Appropriate Use Criteria Committee (lymphoproliferative subgroup). PubMed was searched for relevant articles, including CTCL and NGS, for clonality from 1967 to 2022. Thirteen studies were included in the analysis. The skin was the most commonly assayed compartment with TCR NGS. Sensitivity for TCR NGS in the skin ranged between 69% and 100%, compared to 44%\u201372% for polymerase chain reaction (PCR)\u2010capillary electrophoresis. Specificity for TCR NGS in the skin ranged from 86% to 100%, compared to 77%\u201388% for PCR capillary electrophoresis. TCR NGS was also reported to have potential prognostic value in CTCL and can also be used to detect relapse and\/or minimal residual disease after treatment.<\/jats:p>","DOI":"10.1111\/cup.14694","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T07:18:40Z","timestamp":1721287120000},"page":"813-819","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Assessing T\u2010cell receptor clonality by next\u2010generation sequencing in atypical cutaneous lymphoid infiltrates and cutaneous T\u2010cell lymphoma: A scoping review"],"prefix":"10.1111","volume":"51","author":[{"given":"Michi M.","family":"Shinohara","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Washington  Seattle Washington USA"},{"name":"Department of Pathology and Laboratory Medicine University of Washington  Seattle Washington 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