{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:33:42Z","timestamp":1779114822097,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>NRAS<\/jats:italic> Q61 mutations are driver genetic alterations associated with common melanocytic nevi. Herein, we describe a case of <jats:italic>NRAS<\/jats:italic>\u2010mutant melanocytic tumor with a blue nevus\u2010like morphology. A 71\u2010year\u2010old Japanese man presented with a 4.6\u2010mm nodule on his back. Histopathological examination revealed a dense distribution of spindle\u2010shaped melanocytes in the upper dermis and a sparse distribution of dendritic melanocytes in the mid\u2010dermis. The vertical periadnexal extension reached the deep dermis at the center of the tumor. A small junctional component, hyperpigmentation, sclerotic stroma, mild nuclear atypia, and a few mitotic figures were observed. Immunohistochemical examination revealed no PRAME expression and preserved p16 expression. Diffuse RASQ61R immunoreactivity was observed in these tumor cells. Nuclear \u03b2\u2010catenin expression was not observed. Targeted RNA sequencing revealed two mutations, <jats:italic>NRAS<\/jats:italic> c.182A&gt;G (Q61R) and <jats:italic>FGFR2<\/jats:italic> c.\u2010157A&gt;G, but no other pathogenic alterations such as <jats:italic>BRAF<\/jats:italic>, <jats:italic>GNAQ<\/jats:italic>, <jats:italic>GNA11<\/jats:italic>, <jats:italic>CTNNB1<\/jats:italic>, <jats:italic>PRKAR1A<\/jats:italic>, or <jats:italic>IDH1<\/jats:italic> mutations or kinase gene fusions. The histopathology fits that of compound\u2010type blue nevus, which is called \u201cKamino nevus\u201d; however, this tumor was genetically considered to be on the spectrum of conventional acquired melanocytic nevi but not on that of blue nevi. Morphologically, <jats:italic>NRAS<\/jats:italic>\u2010driven melanocytic nevi resemble blue nevi without <jats:italic>IDH1<\/jats:italic><jats:sup>R132C<\/jats:sup> coexistence.<\/jats:p>","DOI":"10.1111\/cup.14709","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T09:53:15Z","timestamp":1724406795000},"page":"948-953","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>NRAS<\/i><sup>Q61R<\/sup>\u2010driven atypical melanocytic tumor with blue nevus\u2010like morphology: A case report"],"prefix":"10.1111","volume":"51","author":[{"given":"Tsubasa","family":"Hiraki","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Shizuoka Cancer Center Hospital  Sunto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Hamamatsu Medical Center  Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Misawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu Medical Center  Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Yunoki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu Medical Center  Hamamatsu Japan"},{"name":"Department of Dermatology &amp; Skin Oncology Chutoen General Medical Center  Kakegawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4165-1809","authenticated-orcid":false,"given":"Keisuke","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Shizuoka Cancer Center Hospital  Sunto Japan"},{"name":"Department of Pathology Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital  Tokyo Japan"},{"name":"Department of Anatomic Pathology Tokyo Medical University  Tokyo Japan"},{"name":"Department of Diagnostic Pathology Chutoen General Medical Center  Kakegawa Japan"},{"name":"Department of Diagnostic Pathology and Cytology Osaka International Cancer Institute  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"WHO Classification of Skin Tumours","author":"Bastian BC","year":"2023"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.12.033"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07586"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.201"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001299"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100286"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100264"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181f0a749"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4116"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22071"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.09.013"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqz209"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12389"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2024.100469"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001500"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182498be5"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201000758"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428\u2010019\u201002533\u20109"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001888"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000002556"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb\u20102001\u20102\u20103\u2010reviews3005"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.07.011"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1990.01670340082013"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2017.05.001"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428\u2010019\u201002667\u2010w"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010199903000\u201000005"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2021.12.293"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T08:07:25Z","timestamp":1730707645000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.14709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,23]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/cup.14709"],"URL":"https:\/\/doi.org\/10.1111\/cup.14709","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,23]]},"assertion":[{"value":"2024-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}