{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T03:06:38Z","timestamp":1769742398819,"version":"3.49.0"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Cutaneous immune\u2010related adverse events (irAEs) of immunotherapies, such as anti\u2010programmed cell death protein\u20101 (PD\u20101), suggest that immune checkpoint factors may contribute to the pathobiology of lichenoid interface dermatitis in immunotherapy\u2010na\u00efve patients. Our study aimed to describe innate and adaptive immune markers via immunohistochemical (IHC) staining of lichenoid interface dermatoses. We studied the staining patterns of PD\u2010L1, STING, IL\u201036 gamma, CD8, PD\u20101, and LAG\u20103 in five interface dermatoses: oral lichen planus (LP) (<jats:italic>n<\/jats:italic>\u2009=\u200910), cutaneous LP (<jats:italic>n<\/jats:italic>\u2009=\u200910), chronic cutaneous lupus erythematosus (CLE) (<jats:italic>n<\/jats:italic>\u2009=\u200911), erythema multiforme (EM) (<jats:italic>n<\/jats:italic>\u2009=\u200911), and toxic epidermal necrolysis (TEN) (<jats:italic>n<\/jats:italic>\u2009=\u200913), by immunohistochemistry (IHC) analysis. Expression was evaluated semi\u2010quantitively according to the percentage of keratinocytes and dermal lymphocytes stained compared to keratinocytes and resident pericapillary lymphocytes in normal human skin. All interface dermatoses evaluated showed increased expression of PD\u2010L1 on keratinocytes and LAG\u20103 in lymphocytes. STING was increased on the keratinocytes of most specimens. Expression of IL\u201036 gamma, in basal layer keratinocytes was more extensive in oral LP and cutaneous LP and varied in CLE, EM, and TEN. Lymphocytic infiltration expressing PD\u20101 was elevated in oral LP, cutaneous LP, and CLE. Current thinking is that interface dermatitis is the result of a cell\u2010mediated immune reaction involving cytotoxic CD8<jats:sup>+<\/jats:sup> T\u2010cell\u2010mediated apoptosis of keratinocytes. The findings of this study suggest that in addition to cell\u2010mediated immunity, innate immune factors may contribute to pathobiology.<\/jats:p>","DOI":"10.1111\/cup.14736","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T12:03:35Z","timestamp":1729857815000},"page":"262-265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immunohistochemical Expression of Immune Regulatory Proteins in Interface Dermatoses"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6097-1602","authenticated-orcid":false,"given":"Sarah Grace","family":"McAlpine","sequence":"first","affiliation":[{"name":"University of North Carolina at Chapel Hill School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Culton","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill School of Medicine  Chapel Hill North Carolina USA"},{"name":"Department of Dermatology University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Duplisea","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Liu","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill School of Medicine  Chapel Hill North Carolina USA"},{"name":"Department of Dermatology University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si On","family":"Lim","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill School of Dentistry  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9185-3548","authenticated-orcid":false,"given":"Paul","family":"Googe","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill School of Medicine  Chapel Hill North Carolina USA"},{"name":"Department of Dermatology University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378\u20106323.82389"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.622511"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2019.10.015"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.105"},{"key":"e_1_2_5_6_1","unstructured":"PD\u2010L1 IHC 22C3 Pharm Dx Interpretation Manual \u201cNSCLC.\u201d2021."},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1254915"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0257356"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001816"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/pore.2022.1610521"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T23:20:29Z","timestamp":1741735229000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.14736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,25]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/cup.14736"],"URL":"https:\/\/doi.org\/10.1111\/cup.14736","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,25]]},"assertion":[{"value":"2023-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}