{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:38:01Z","timestamp":1789749481657,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T00:00:00Z","timestamp":1729987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pyoderma gangrenosum (PG) is a rare necrotizing neutrophilic dermatosis driven by monokines and cytokines elaborated by monocytes and autoreactive T cells, respectively. Th1\u2010mediated autoimmune disorders and myeloproliferative disease are among the potential disease associations. More recently, certain medications were implicated, including TNF\u2010alpha inhibitors, rituximab, and IL\u201017A inhibitors, such as secukinumab, where the development of PG is held to represent a cutaneous immune adverse effect. We present two patients who developed an autoinflammatory syndrome resembling PG in the setting of drug therapy with agents exhibiting an IL\u201017A inhibitory effect. The drugs were erunumab in one and secukinumab in the other. One patient received the anti\u2010calcitonin gene\u2010related peptide targeted therapy, erenumab, for migraine prophylaxis. While this drug has not been previously implicated in the development of PG, it can cause IL\u201017A blockade. The other patient was on secukinumab, a monoclonal antibody that selectively targets IL\u201017A. We documented a microenvironment enriched in IL\u201017A, emphasizing that the blockade impacts the functionality of the receptor as opposed to a quantitative reduction in IL\u201017A production by T cells. Qualitative functional IL\u201017A blockade could result in a paradoxical increase in IL\u201023, a pro\u2010inflammatory cytokine that may contribute to the influx of neutrophils pathogenetically implicated in PG.<\/jats:p>","DOI":"10.1111\/cup.14740","type":"journal-article","created":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T08:05:32Z","timestamp":1730016332000},"page":"112-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pyoderma Gangrenosum Associated With Iatrogenic Interleukin 17A Blockade: A Report of Two Cases and\u00a0a\u00a0Review of the Literature"],"prefix":"10.1111","volume":"53","author":[{"given":"Cynthia M.","family":"Magro","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Crowson","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Oklahoma and Pathology Laboratory Associates  Tulsa Oklahoma USA"},{"name":"Department of Surgery University of Oklahoma and Pathology Laboratory Associates  Tulsa Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5165-6884","authenticated-orcid":false,"given":"Taylor","family":"Kalomeris","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine New York Presbyterian\/Weill Cornell Medicine  New York New\u00a0York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Nuovo","sequence":"additional","affiliation":[{"name":"Department of Pathology Ohio State University Medical Center  Columbus Ohio 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