{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:32:27Z","timestamp":1790397147094,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Kaposi sarcoma is a human herpesvirus 8\u2013associated angio\u2010proliferative tumor arising from lymphatic endothelial cells. Four clinical subtypes are known: classic, epidemic, endemic, and iatrogenic. The development of Kaposi sarcoma and lymphedema may be interlinked, where each condition could potentially support the progression of the other. Post\u2010mastectomy lymphedema is a commonly recognized complication following radical mastectomy. Angiosarcoma is the most frequently reported neoplasm in such a situation. We present a 72\u2010year\u2010old female who developed Kaposi sarcoma on the same side of mastectomy 9\u2009years following her initial diagnosis and treatment for cancer breast. The diagnosis of Kaposi sarcoma was based on the histopathologic findings and was confirmed with immunohistochemical staining for human herpes virus 8 and D2\u201040. Lymphedema may be associated with local immune suppression manifested in the form of defective cell\u2013mediated immunity and antigen\u2010presenting cell migration defect which may facilitate development of neoplasms. It is important to differentiate Kaposi sarcoma from other vascular tumors which may have a much worse prognosis. Patients with lymphedema should receive appropriate management and undergo long\u2010term follow\u2010up for early detection of any potential malignancies.<\/jats:p>","DOI":"10.1111\/cup.14751","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T03:34:31Z","timestamp":1730777671000},"page":"80-84","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Kaposi Sarcoma in the Context of Post\u2010Modified Radical Mastectomy: A New Case Report and Brief Review"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2141-2296","authenticated-orcid":false,"given":"Rasha Mahmoud","family":"Genedy","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Dermatology, Venereology, and Andrology Department Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2095-0615","authenticated-orcid":false,"given":"Naglaa Mohamed","family":"El Sayed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dermatology, Venereology, and Andrology Department Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdmv.2023.10.007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.155.2.2115258"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(13)70076\u20107"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15736"},{"issue":"3","key":"e_1_2_7_6_1","first-page":"680","article-title":"Clinicopathologic Features of Stewart\u2013Treves Syndrome","volume":"12","author":"Wang L. 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