{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T09:25:09Z","timestamp":1751448309244,"version":"3.32.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Xeroderma pigmentosum (XP) is a genodermatosis, characterized both by premature aging and significantly increased risk of non\u2010melanoma and melanoma skin cancers at an early age. However, limited literature is available on the common histopathological subtypes of basal cell carcinoma (BCC) in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this ambispective case series, we recruited patients of XP who had either a currently present skin tumor or previously excised one, provided their histopathological sections were available. Cytogenetic analysis was performed in all the patients. The histopathological findings were recorded by two trained dermatopathologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 22 recruited patients with XP, 12 patients had 41 BCCs, and 23 (56.09%) of them showed a high\u2010risk histopathological subtype. Basosquamous carcinoma (10, 24.39%) was the most frequent high\u2010risk tumor followed by infiltrative variant (7, 17.07%). Mixed\u2010histopathological subtypes were noted in six (14.63%) cases, and all of them had a high\u2010risk component. The low\u2010risk subtypes included nodular (<jats:italic>n<\/jats:italic>\u2009=\u200917, 41.46%) and superficial BCC (1, 2.43%). Though a deep dermal involvement was seen in 27 (65.85%) lesions, none showed a perineural invasion or necrosis. Three (7.31%) lesions showed ulceration, while 10 (24.39%) showed presence of pigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A frequent occurrence of high\u2010risk basal cell carcinoma was noted in patients with XP\u2010mandating creation of appropriate treatment and follow\u2010up strategies in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14753","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T05:29:26Z","timestamp":1731389366000},"page":"154-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Frequent Occurrence of High\u2010Risk Basal Cell Carcinoma in Xeroderma Pigmentosum: A Histopathological Insight From an Indian Cohort"],"prefix":"10.1111","volume":"52","author":[{"given":"Shafaque","family":"Imran","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivangi","family":"Dagar","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3314-1734","authenticated-orcid":false,"given":"Rhea","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devesh Kumar Jag","family":"Swaroop","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somesh","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudheer","family":"Arava","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaushal K.","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neetu","family":"Bhari","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2010.083022"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.123.2.241"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13979"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2016.05.005"},{"volume-title":"WHO Classification of Skin Tumors","year":"2023","author":"Elder D. 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