{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T02:47:38Z","timestamp":1749091658746,"version":"3.37.0"},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T00:00:00Z","timestamp":1733529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Angiosarcoma is a rare and aggressive malignancy of endothelial cells with multiple subtypes. Foamy cell angiosarcoma is a rare variant in which endothelial cells demonstrate \u201cfoamy\u201d cytoplasmic change. We present the case of a 59\u2010year\u2010old male who presented with progressive erythema and swelling of the midface and bilateral eyelids. Two biopsies obtained 3 months apart showed an infiltrate of foamy mononuclear cells in the deep dermis, resembling a xanthomatous histiocytic process. Clinical work\u2010up for disorders including Erdheim\u2010Chester disease, Langerhans cell histiocytosis, and necrobiotic xanthogranuloma was negative. Nine months later, a third set of biopsies was performed showing a similar infiltrate of foamy histiocyte\u2010like cells within the deep dermis. However, there was also a dermal proliferation of irregular vascular spaces lined by atypical endothelial cells, diagnostic of angiosarcoma. Subsequent immunohistochemical stains demonstrated expression of CD31 and ERG within the foamy cells in both sets of biopsies, strongly suggesting endothelial lineage and supporting a diagnosis of foamy cell angiosarcoma. CD34 was negative. This case represents a very unusual presentation of angiosarcoma and a diagnostic conundrum. In cases such as these, especially when features of a vascular proliferation are absent, ERG appears to be the most useful marker for differentiating foamy cell angiosarcoma from histopathologic mimickers.<\/jats:p>","DOI":"10.1111\/cup.14772","type":"journal-article","created":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T12:50:03Z","timestamp":1733575803000},"page":"189-193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Foamy Cell Angiosarcoma Resembling a Xanthomatous Histiocytic Infiltrate Without Evidence of Vascular Malignancy"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1823-3676","authenticated-orcid":false,"given":"Jolee","family":"Potts","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Dermatology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George J.","family":"Harocopos","sequence":"additional","affiliation":[{"name":"Department of Pathology and\u00a0Immunology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Ophthalmology and Visual Sciences Washington\u00a0University School of Medicine  St.\u00a0Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4667-9752","authenticated-orcid":false,"given":"Aaron J.","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Dermatology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Pathology and\u00a0Immunology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,7]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_5_2_1","DOI":"10.1111\/j.1600\u20100560.2010.01512.x"},{"doi-asserted-by":"publisher","key":"e_1_2_5_3_1","DOI":"10.1097\/dad.0000000000000052"},{"doi-asserted-by":"publisher","key":"e_1_2_5_4_1","DOI":"10.1093\/annonc\/mdm381"},{"doi-asserted-by":"publisher","key":"e_1_2_5_5_1","DOI":"10.1093\/ajcp\/96.1.25"},{"doi-asserted-by":"publisher","key":"e_1_2_5_6_1","DOI":"10.1136\/jclinpath\u20102014\u2010202629"},{"doi-asserted-by":"publisher","key":"e_1_2_5_7_1","DOI":"10.1111\/j.1365\u20103083.2008.02091.x"},{"doi-asserted-by":"publisher","key":"e_1_2_5_8_1","DOI":"10.1155\/2016\/2539781"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T10:00:03Z","timestamp":1739268003000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.14772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,7]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/cup.14772"],"URL":"https:\/\/doi.org\/10.1111\/cup.14772","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"type":"print","value":"0303-6987"},{"type":"electronic","value":"1600-0560"}],"subject":[],"published":{"date-parts":[[2024,12,7]]},"assertion":[{"value":"2024-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}