{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:18:44Z","timestamp":1789957124353,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Erythroderma is a dermatologic condition characterized by widespread red and scaly skin. The causes include, but are not limited to, psoriasis, eczema, drug eruptions, pityriasis rubra pilaris (PRP), and cutaneous T\u2010cell lymphoma. Most of these are typified by Type 2 (e.g., eczema) or Type 17 (e.g., psoriasis) immune activation. However, since the clinicopathologic features of erythroderma can be nonspecific, assays that determine the underlying immune activation status are desirable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>IL\u201013 RNA in\u00a0situ hybridization and IL\u201036 immunohistochemistry were performed on 30 specimens of erythroderma, to ascertain Type 2 and Type 17 immune signatures, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Specimens of erythrodermic psoriasis and PRP showed strong expression of IL\u201036 and less than one IL\u201013\u2010positive cell per millimeter. Conversely, those of spongiotic dermatitis showed low expression of IL\u201036 and greater than one IL\u201013\u2010positive cell per millimeter. Most specimens of spongiotic, psoriasiform dermatitis demonstrated low IL\u201036 expression and greater than one IL\u201013\u2010positive cell per millimeter, but a subset showed high IL\u201036 expression and greater than one IL\u201013\u2010positive cell per millimeter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We developed a Type 2\/17 immune signature classifier based on cytokine profiling, which showed that cases of erythroderma fall within distinct categories of immune activation. This categorization may have utility in guiding clinical decisions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.14775","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T10:35:33Z","timestamp":1733999733000},"page":"235-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cytokine Profiling of Erythroderma Biopsies Reveals Types 2 and 17 Immune Activation Status"],"prefix":"10.1111","volume":"52","author":[{"given":"Tatsiana","family":"Pukhalskaya","sequence":"first","affiliation":[{"name":"Department of Dermatology and Pathology University of California  California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Finkelstein","sequence":"additional","affiliation":[{"name":"Cooper Medical School of Rowan University  Camden New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dacia 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