{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:57:41Z","timestamp":1788573461021,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Spitz melanoma is extremely rare, and only a few cases of distant metastases have been reported. Herein, we describe a case of Spitz melanoma with multiple distant metastases. A 37\u2010year\u2010old woman presented with a 5.5\u2010mm\u2010diameter nodule on the right lower leg. She experienced multiple distant metastases, involving the lungs, liver, thyroid, stomach, ovary, bones, and skin, along with multiple lymph node metastases within 1\u2009year. The patient succumbed to the disease 1\u2009year and 6\u2009months following the first excision. Histopathological examination revealed a dense distribution of large solid nests comprising large, atypical epithelioid melanocytes with abundant eosinophilic cytoplasm in the upper dermis. Diffuse PRAME and loss of p16 immunoexpression profiles were observed. Targeted DNA and Sanger sequencing revealed an in\u2010frame <jats:italic>MAD1L1<\/jats:italic>(e16)<jats:italic>::BRAF<\/jats:italic>(e9) fusion in both primary tumor and metastatic subcutaneous lesion. A review of previously reported cases confirmed as Spitz melanoma with distant metastases (<jats:italic>n<\/jats:italic>\u2009=\u20097) revealed a broad age range (11\u201371\u2009years, median 46\u2009years), high mortality (5\/7), frequent <jats:italic>BRAF<\/jats:italic> fusions (6\/7), and recurrent <jats:italic>TERT<\/jats:italic> promotor mutations and <jats:italic>CDKN2A\/B<\/jats:italic> deletions. This report adds valuable insights into our understanding of the clinical and genetic characteristics of Spitz melanoma with distant metastases.<\/jats:p>","DOI":"10.1111\/cup.14779","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T10:53:54Z","timestamp":1735210434000},"page":"199-205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fatal Spitz Melanoma With <i>MAD1L1::BRAF<\/i> Fusion: A Case Report and Literature Review"],"prefix":"10.1111","volume":"52","author":[{"given":"Tsubasa","family":"Hiraki","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Shizuoka Cancer Center Hospital  Sunto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6297-3325","authenticated-orcid":false,"given":"Satoshi","family":"Hirakawa","sequence":"additional","affiliation":[{"name":"Department of Supportive Care in Cancer Seirei Hamamatsu General Hospital  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0568-3811","authenticated-orcid":false,"given":"Yoshiro","family":"Otsuki","sequence":"additional","affiliation":[{"name":"Department of Pathology Seirei Hamamatsu General Hospital  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Kajimoto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Hyogo Cancer Center  Akashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4165-1809","authenticated-orcid":false,"given":"Keisuke","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Shizuoka Cancer Center Hospital  Sunto Japan"},{"name":"Department of Diagnostic Pathology Hyogo Cancer Center  Akashi Japan"},{"name":"Department of Pathology Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital  Tokyo Japan"},{"name":"Department of Anatomic Pathology Tokyo Medical University  Tokyo Japan"},{"name":"Department of Diagnostic Pathology Chutoen General Medical Center  Kakegawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakuni","family":"Serizawa","sequence":"additional","affiliation":[{"name":"Drug Discovery and Development Division Shizuoka Cancer Center Research Institute  Sunto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181f0a749"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4116"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000187"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000387"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379\u2010020\u201000658\u2010w"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001235"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001074"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379\u2010020\u201000678\u20106"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8174"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.12.031"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.14062"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12884"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13842"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001213"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379\u2010019\u20100384\u20108"},{"key":"e_1_2_8_17_1","volume-title":"Spitz Tumours. 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WHO Classification of Skin Tumours. 5th Edition (\u03b2 Version)","author":"Gerami P.","year":"2023"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010019\u20100373\u2010y"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12388"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.37"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.14263"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100149"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29825"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000533822"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep11200"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001070"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.14356"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002302"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T10:00:32Z","timestamp":1739268032000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.14779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,26]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/cup.14779"],"URL":"https:\/\/doi.org\/10.1111\/cup.14779","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,26]]},"assertion":[{"value":"2024-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}