{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T12:34:35Z","timestamp":1788611675670,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Digital Papillary Adenocarcinoma (DPA) is a rare tumor that can cause metastasis and death. It can morphologically mimic benign sweat gland tumors. In 2022, the novel association of HPV\u201042 and DPA was discovered by means of DNA sequencing. In this scoping review, we aimed to systematically evaluate alternatives to HPV\u201042 molecular sequencing. Of 87 articles on DPA identified in a PUBMED meta\u2010search, eight met the inclusion criteria. We found that DNA sequencing for HPV\u201042 is most sensitive (94%). Comparable tests included HPV\u201042 in\u00a0situ hybridization (ISH), which had 82% sensitivity, and p16 immunohistochemistry, which had 70%\u201375% sensitivity. We further evaluated the performance of HPV\u201042 ISH and performed a stratified analysis of HPV\u201042 ISH\u2010negative DPA cases. There was a statistically significant difference in HPV\u201042 positivity in patients younger than and older than 60\u2009years old (<jats:italic>p<\/jats:italic>\u2009=\u20090.02). We recommend HPV\u201042 ISH for cases with equivocal morphology from patients aged over 60\u2009years. Tumors with equivocal morphology from patients under the age of 60\u2009years should be sequenced for HPV\u201042. For cases with classic morphology, p16 can be used to support the diagnosis, but molecular testing for HPV\u201042 is unnecessary.<\/jats:p>","DOI":"10.1111\/cup.14823","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T07:09:36Z","timestamp":1749625776000},"page":"590-594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Review of Literature to Determine Recommended Application of <scp>HPV<\/scp>\u201042 Molecular Testing for Digital Papillary Adenocarcinoma"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6932-6061","authenticated-orcid":false,"given":"Michelle Y.","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Pathology and Anatomical Sciences, Jacobs School of Medicine and Biomedical Sciences University at Buffalo, the State University of New York  Buffalo New York 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