{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T22:04:19Z","timestamp":1781733859013,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>While early reports of <jats:italic>CRTC1::TRIM11<\/jats:italic> cutaneous tumors suggested a predominantly indolent clinical course, a few cases have been documented with lymph node and distant metastases. We report herein a metastasizing tumor with a lethal outcome. It presented as a subcutaneous mass on the back of a 17\u2010year\u2010old teenager. Histopathologically, the tumor was subepidermal and composed of amelanotic spindle and epithelioid cells with nuclear pleomorphism. The tumor cells were immunoreactive for Sox10 and S100, focally positive for Melan\u2010A, and negative for PRAME. Whole genome and whole transcriptome sequencing revealed a <jats:italic>CRTC1::TRIM11<\/jats:italic> fusion as well as a number of additional genetic and genomic aberrations. No <jats:italic>TERT<\/jats:italic> promoter gene mutation was identified. The patient developed metastases to the lung, lymph nodes, and soft tissue. The tumor was refractory to various treatments. The patient died of widely metastatic disease 18\u2009months after clinical presentation. This case expands our knowledge of the clinical, pathologic, and molecular findings of <jats:italic>CRTC1::TRIM11<\/jats:italic> cutaneous tumors. In contrast to other reported cases, the tumor of our patient contained additional genomic aberrations. More cases are needed to assess what factors are relevant for the prognosis of <jats:italic>CRTC1::TRIM11<\/jats:italic> cutaneous tumors to help distinguish those with indolent from those with aggressive behavior.<\/jats:p>","DOI":"10.1111\/cup.14824","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T04:40:22Z","timestamp":1748839222000},"page":"528-532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Malignant <scp>CRTC1<\/scp>::<scp>TRIM11<\/scp> Cutaneous Tumor With Lethal Outcome: Histopathologic and Molecular Findings"],"prefix":"10.1111","volume":"52","author":[{"given":"Meghan E.","family":"Beatson","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James 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