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This comprehensive literature review challenges that notion by exploring its histopathologic, immunopathologic, and molecular overlap with mycosis fungoides (MF). Through examination of lymphocyte populations, T\u2010lymphocyte clonality, and aberrant immunohistochemical phenotypes, our findings indicate that a subset of PL cases, particularly those exhibiting a loss of pan\u2010T\u2010cell markers (CD2, CD5, CD7), or T\u2010cell clonality, may have a closer association with MF. These findings highlight the need for heightened clinical awareness and surveillance in select PL cases, as early identification of MF may improve patient outcomes.<\/jats:p>","DOI":"10.1111\/cup.14856","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T01:24:32Z","timestamp":1757985872000},"page":"785-794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Overlapping Clinicopathological Presentations of Pityriasis Lichenoides and Mycosis Fungoides"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9333-9614","authenticated-orcid":false,"given":"Olivia","family":"Pierog","sequence":"first","affiliation":[{"name":"Department of Dermatology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariah","family":"Estill","sequence":"additional","affiliation":[{"name":"Department of Dermatology Georgetown University School of Medicine  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslaw","family":"Jedrych","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sima","family":"Rozati","sequence":"additional","affiliation":[{"name":"Department of Dermatology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Marchalik","sequence":"additional","affiliation":[{"name":"Department of Dermatology Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13396"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.07.058"},{"key":"e_1_2_10_4_1","volume-title":"Dermatopathology","author":"Elston D. 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