{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T18:25:53Z","timestamp":1777141553460,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Syringomatous tumor of the nipple (SyT) is a rare benign tumor that arises in the nipple or areolar region. Due to its locally infiltrative growth pattern, it is often misdiagnosed as a malignant tumor. SyT primarily occurs in middle\u2010aged women, with a reported mean age of onset of 46.1\u2009years. Fewer than 100 cases have been documented in the literature to date, and occurrence in adolescents is exceedingly rare. This case report describes a rare instance of SyT in a 16\u2010year\u2010old asymptomatic female, who presented with progressive unilateral nipple enlargement over 5\u2009years. Breast ultrasound and subsequent surgical excision were performed, and the final histopathological diagnosis confirmed SyT. This report highlights the imaging and pathological features of SyT and discusses main differential diagnoses, emphasizing the importance of accurate clinical recognition and appropriate management to avoid overtreatment. It provides valuable insights to aid in the diagnosis and clinical decision\u2010making for this rare entity.<\/jats:p>","DOI":"10.1111\/cup.14865","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:31:14Z","timestamp":1759483874000},"page":"759-764","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Syringomatous Tumor of the Nipple in an Adolescent Female: A Rare Cutaneous Adnexal Neoplasm With Distinct Histopathologic Features"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6460-2647","authenticated-orcid":false,"given":"Shilong","family":"Zhang","sequence":"first","affiliation":[{"name":"Center of Breast and Thyroid Surgery, Department of General Surgery The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University &amp; The Second Affiliated Hospital of Chengdu, Chongqing Medical University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8923-9576","authenticated-orcid":false,"given":"Jian","family":"Wu","sequence":"additional","affiliation":[{"name":"Center of Breast and Thyroid Surgery, Department of General Surgery The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University &amp; The Second Affiliated Hospital of Chengdu, Chongqing Medical University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198307080-00003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.7521"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2024.48.1.37845"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14091"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338370"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/njcp.njcp_1_20"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2015.06.040"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12358"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.5858\/133.9.1487"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20104741.2007.00527.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.19586"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1075\u2010122X.2004.21518.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010198903000\u201000003"},{"issue":"7","key":"e_1_2_9_15_1","first-page":"302","article-title":"Syringomatous Adenoma of the Nipple With Associated Invasive Carcinoma: A Case Report","volume":"75","author":"Pratt D.","year":"2022","journal-title":"South Dakota Medicine"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3348\/jksr.2020.0184"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.13951"},{"issue":"4","key":"e_1_2_9_18_1","first-page":"201","article-title":"Syringomatous Adenoma of the Nipple","volume":"51","author":"Biernat W.","year":"2000","journal-title":"Polish Journal of Pathology"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002063"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100560.2009.01267.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.14865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T02:13:31Z","timestamp":1762136011000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.14865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,3]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/cup.14865"],"URL":"https:\/\/doi.org\/10.1111\/cup.14865","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,3]]},"assertion":[{"value":"2025-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}