{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T02:16:51Z","timestamp":1762136211181,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Eccrine spiradenomas are benign sweat gland neoplasms that rarely undergo malignant transformation. Carcinosarcoma arising from an eccrine spiradenoma is exceptionally rare. A 41\u2010year\u2010old male presented with a rapidly growing neck\/shoulder mass, progressive numbness, spasticity, and weakness. Further workup additionally revealed an epidural mass with spinal cord compression. Both masses were excised and predominantly showed morphologic features of high\u2010grade osteosarcoma, with overtly malignant spindled cells producing lace\u2010like osteoid. However, a single section from the upper back mass contained a roughly 2\u2009mm focus of conventional eccrine spiradenoma, with an adjacent small focus having features of a poorly differentiated non\u2010small cell carcinoma. The final diagnosis was that of a high\u2010grade carcinosarcoma with heterologous osteosarcomatous differentiation, arising from a pre\u2010existing eccrine spiradenoma, with metastasis to the T4\u20105 epidural region. The patient experienced rapid regrowth of the spinal mass and underwent radiotherapy but had unresectable metastatic disease at 2\u2009months follow\u2010up. We describe what is to our knowledge only the 21st example of carcinosarcoma arising from eccrine spiradenoma, mimicking metastatic osteosarcoma. Awareness of this very rare entity, careful sampling, close microscopic examination, and, in selected cases, ancillary immunohistochemistry are the keys to making this challenging diagnosis.<\/jats:p>","DOI":"10.1111\/cup.14867","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T03:58:31Z","timestamp":1756871911000},"page":"743-748","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Carcinosarcoma Arising in an Eccrine Spiradenoma and Presenting With Metastasis: Case Report and Literature Review"],"prefix":"10.1111","volume":"52","author":[{"given":"Lisa M.","family":"Marinelli","sequence":"first","affiliation":[{"name":"Department of Dermatology, Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jared M.","family":"Orrock","sequence":"additional","affiliation":[{"name":"Department of Pathology Intermountain Medical Center  Murray Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew L.","family":"Folpe","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"e_1_2_8_2_1","series-title":"WHO Classification of Tumours Series","volume-title":"WHO Classification of Tumours Editorial Board. 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