{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T22:03:31Z","timestamp":1781733811895,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Clear cell sarcoma (CCS) is a rare sarcoma that typically arises in the deep soft tissue of the extremities. We describe two patients with molecularly confirmed CCS in genital skin. Patient 1 was a 22\u2010year\u2010old woman with a vulvar mass, and Patient 2 was a 25\u2010year\u2010old man with a scrotal plaque. Histopathological examination in each case revealed a cellular tumor distributed in nests and sheets, composed of epithelioid and spindled cells. The tumor cells exhibited clear and eosinophilic cytoplasm, vesicular nuclei, and prominent nucleoli. Immunohistochemical analysis demonstrated that both tumors expressed Sox10 and HMB45. FISH testing revealed\n                    <jats:italic>EWSR1<\/jats:italic>\n                    rearrangements in both cases, and further NGS analysis in Case 1 confirmed the presence of an\n                    <jats:italic>EWSR1<\/jats:italic>\n                    \u2010\n                    <jats:italic>ATF1<\/jats:italic>\n                    fusion. To date, only 3 cases of CCS have been reported involving the genital region, all originating in deep soft tissues. Our report expands the known anatomical sites of cutaneous clear cell sarcoma involvement.\n                  <\/jats:p>","DOI":"10.1111\/cup.70001","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:42:31Z","timestamp":1760416951000},"page":"142-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cutaneous Clear Cell Sarcoma in the Genital Region: A Report of Two Cases at an Unusual Location"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7483-2243","authenticated-orcid":false,"given":"Zhongqin","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Elizabeth Reed","family":"Shenk","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Holliday","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina V.","family":"Hunter","sequence":"additional","affiliation":[{"name":"The Dermatology Group Limited Liability Company  Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelin","family":"Sagut","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Dermatologic Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Forcucci","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk M.","family":"Elston","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Dermatologic Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(196509)18:9<1163::AID\u2010CNCR2820180916>3.0.CO;2\u20100"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019\u20105154.53193"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181c7d8b2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001404"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI146301"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyad083"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046\u20108177(86)80468\u20103"},{"issue":"1","key":"e_1_2_7_9_1","first-page":"43","article-title":"Clear Cell Sarcoma of the Penis: A Case Report","volume":"3","author":"Ito T.","year":"2015","journal-title":"American Journal of Clinical and Experimental Urology"},{"key":"e_1_2_7_10_1","first-page":"215","article-title":"Clear Cell Sarcoma of Vulva. A Case Report","volume":"52","author":"N\u011bmejcov\u00e1 K.","year":"2016","journal-title":"Ceskoslovenska Pathologie"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13659"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001658"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.32010"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12197"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.14390"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12099"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2021.05.097"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974\u20102727.98677"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3182473190"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13812"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001331"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2024.06.026"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/984096"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12480"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2024.100438"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.14543"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T19:25:50Z","timestamp":1767813950000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.70001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,13]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/cup.70001"],"URL":"https:\/\/doi.org\/10.1111\/cup.70001","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,13]]},"assertion":[{"value":"2025-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}