{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:45:13Z","timestamp":1792568713838,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    An otherwise healthy 82\u2010year\u2010old woman presented with recurrent, asymptomatic erythematous papulo\u2010nodular lesions on the face and extremities. A skin biopsy revealed a dense, non\u2010epidermotropic lymphohistiocytic infiltrate with granulomatous features and a mixed population of medium\u2010sized atypical lymphoid cells and plasma cells. Immunohistochemistry demonstrated a predominant CD4+ T\u2010cell population with a T\u2010follicular helper (TFH) phenotype (PD1+, CXCL13+, BCL6+), admixed with EBV\u2010negative monotypic B\u2010cells. Clonality was confirmed for both T and B cells by BIOMED2 PCR, and a\n                    <jats:italic>RHOA<\/jats:italic>\n                    p.G17V mutation was identified. Next\u2010generation sequencing revealed additional mutations in TET2 and DNMT3A. Complete staging studies showed no nodal or visceral involvement. A minimal circulating population (0.11%) of atypical CD4+ T\u2010cells with surface CD3 loss and TFH markers was detected in peripheral blood. Based on clinical and histopathological findings, a diagnosis of primary cutaneous peripheral T\u2010cell lymphoma with TFH phenotype (pcPTCL\u2010TFH) was made. The patient also developed a cutaneous squamous cell carcinoma, in which a peritumoral TFH lymphoid infiltrate with the same clonal features was identified. This case illustrates the diagnostic complexity of pcPTCL\u2010TFH and its potential overlap with systemic TFH\u2010derived lymphomas, underscoring the need for molecular work\u2010up and close clinical follow\u2010up to detect possible extracutaneous progression.\n                  <\/jats:p>","DOI":"10.1111\/cup.70005","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:03:37Z","timestamp":1761894217000},"page":"147-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Primary Cutaneous Peripheral T\u2010Cell Lymphoma With Follicular Helper T\u2010Cell Phenotype"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1303-2422","authenticated-orcid":false,"given":"Nidia","family":"Planella\u2010Fontanillas","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital del Mar Research Institute (IMIM)  Barcelona 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Rovira","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar Research Institute (IMIM)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Gonz\u00e0lez\u2010Farr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital del Mar Research Institute (IMIM)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Barranco\u2010Sanz","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital del Mar Research Institute (IMIM)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7934-9130","authenticated-orcid":false,"given":"Xavier","family":"Calvo","sequence":"additional","affiliation":[{"name":"Laboratori de Citologia Hematol\u00f2gica, Servei de Patologia, Grup de Recerca Translacional en Neopl\u00e0sies Hematol\u00f2giques (GRETNHE) Hospital del Mar Research Institute (IMIM)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Nadal\u2010Pellis\u00e9","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital del Mar Research Institute (IMIM)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Gallardo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar Research Institute (IMIM)  Barcelona Spain"},{"name":"Department of Medicine and Life Sciences (MELIS) Universitat Pompeu Fabra (UPF)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5622-6055","authenticated-orcid":false,"given":"Ramon M.","family":"Pujol","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar Research Institute (IMIM)  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