{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:26:14Z","timestamp":1789032374066,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We present a case of an 84\u2010year\u2010old female with an isolated and asymptomatic 1.0\u2009cm red papule on the left medial knee. A shave biopsy revealed a diffuse atypical lymphoid infiltrate in the dermis with epidermotropism, diffuse expression of CD30 and positive T\u2010cell receptor (TCR) gamma\u2010delta immunophenotype. Fluorescence in\u00a0situ hybridization (FISH) identified a chromosomal rearrangement involving dual\u2010specificity phosphatase\u201022 (\n                    <jats:italic>DUSP22<\/jats:italic>\n                    ) and interferon regulatory factor\u20104 (IRF4). Next generation sequencing (NGS) indicated a low tumor mutational burden with no gene variants. Upon follow\u2010up, there was no evidence of residuum or recurrence. The findings provided the best support for an unusual presentation of lymphomatoid papulosis (LyP) with\n                    <jats:italic>DUSP22\u2010IRF4<\/jats:italic>\n                    gene rearrangement and TCR gamma\u2010delta phenotype. LyP was favored over anaplastic large\u2010cell lymphoma due to spontaneous resolution and lack of systemic involvement. The clinical history and immunohistochemistry excluded mycosis fungoides or other lymphomas. LyP associated with\n                    <jats:italic>DUSP22\u2010IRF4<\/jats:italic>\n                    gene rearrangement is rarely documented in the literature. This is a unique presentation of LyP with concurrent\n                    <jats:italic>DUSP22\u2010IRF4<\/jats:italic>\n                    gene rearrangement and TCR gamma\u2010delta phenotype along with an indolent clinical course. Diagnosing LyP can be particularly challenging due to its histologic similarities with other cutaneous lymphomas, underscoring the importance of distinguishing this relatively benign condition from more aggressive malignancies.\n                  <\/jats:p>","DOI":"10.1111\/cup.70009","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T07:06:27Z","timestamp":1762326387000},"page":"158-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>CD30<\/scp>\n                    \u2010Positive Lymphoproliferative Disorder With\n                    <i>DUSP22\u2010IRF4<\/i>\n                    Rearrangement and Gamma\u2010Delta T\u2010Cell Phenotype: A Novel Indolent Presentation"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3422-3700","authenticated-orcid":false,"given":"Heidi","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Dermatology Dartmouth\u2010Hitchcock Medical Center  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Voronina","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth  Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1859-1892","authenticated-orcid":false,"given":"Aayushma","family":"Regmi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Dartmouth\u2010Hitchcock Medical Center  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle E.","family":"Duprat","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dartmouth\u2010Hitchcock Medical Center  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabnam","family":"Momtahen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Dartmouth\u2010Hitchcock Medical Center  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002200"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-881268"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.14426"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-303305"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107653200"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001941"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2024.07.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2019.01.009"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000002573"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318282d01e"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12601"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15572-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(96)90353-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjidi.2021.100034"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T19:25:55Z","timestamp":1767813955000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.70009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/cup.70009"],"URL":"https:\/\/doi.org\/10.1111\/cup.70009","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,4]]},"assertion":[{"value":"2024-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}