{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:58:13Z","timestamp":1791003493375,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Leprosy shows a broad spectrum of clinical and histopathological features depending on host immunity and disease stage. The characteristic \u201cleprosy pattern\u201d involves superficial and deep dermal infiltrates in perivascular, peri\u2010appendageal, and perineural locations. While tuberculoid leprosy and cutaneous sarcoidosis may occasionally have overlapping histopathology, borderline lepromatous (BL) leprosy demonstrating sarcoidal granulomas is uncommon. We report a 50\u2010year\u2010old female presenting with multiple infiltrated erythematous and hypoesthetic plaques, and asymmetrically thickened peripheral nerves. Skin biopsy from a clinically downgraded lesion revealed sarcoidal granulomas (discrete, non\u2010caseating, with sparse lymphocytic rims); however, the presence of interspersed foamy histiocytes, a distinct Grenz zone, and acid\u2010fast bacilli on Wade\u2010Fite stain, together with clinicopathologic correlation, confirmed a diagnosis of BL leprosy. Ancillary investigations helped rule out sarcoidosis. This case presents the diagnostic challenge created by overlapping granulomatous patterns, and reinforces the importance of detailed clinicopathologic correlation and ancillary testing including mycobacterial stains, especially since slit\u2010skin smears are often negative in borderline cases. Recent studies have shown that changes in immune cell composition within granulomas can influence transition along the leprosy spectrum and may possibly give rise to atypical morphologies (like sarcoidal patterns). Early diagnosis and treatment remain central to leprosy control, and awareness of such presentations can help avoid diagnostic delay in endemic regions.<\/jats:p>","DOI":"10.1111\/cup.70029","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T08:43:10Z","timestamp":1764578590000},"page":"237-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Borderline Lepromatous Leprosy Simulating Sarcoidosis on Histopathology: A Case Report"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2352-3739","authenticated-orcid":false,"given":"Kanya Rani","family":"Vashisht","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8139-6611","authenticated-orcid":false,"given":"Kanika","family":"Sahni","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8778-7958","authenticated-orcid":false,"given":"Ashok","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13064"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijdpdd.ijdpdd_13_18"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2004.00157.x"},{"key":"e_1_2_10_5_1","first-page":"170","volume-title":"Weedon's Skin Pathology","author":"Patterson J. 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S. B.","year":"2019","journal-title":"International Journal of Medical Science and Public Health"},{"issue":"6","key":"e_1_2_10_15_1","first-page":"465","article-title":"Clinico\u2010Histological Correlation in Hansen's Disease: Three\u2010Year Experience at a Newly Established Tertiary Care Center in Central India","volume":"63","author":"Semwal S.","year":"2018","journal-title":"Indian Journal of Dermatology"},{"issue":"3","key":"e_1_2_10_16_1","first-page":"325","article-title":"Significance of Histopathological Classification in Leprosy","volume":"71","author":"Nadkarni N. S.","year":"1999","journal-title":"Indian Journal of Leprosy"},{"issue":"6","key":"e_1_2_10_17_1","first-page":"299","article-title":"Histopathological Correlation of Skin Biopsies in Leprosy","volume":"67","author":"Moorthy B. N.","year":"2001","journal-title":"Indian Journal of Dermatology, Venereology and Leprology"},{"issue":"3","key":"e_1_2_10_18_1","first-page":"433","article-title":"Clinical and Histopathological Correlation in the Classification of Leprosy","volume":"61","author":"Bhatia A. S.","year":"1993","journal-title":"International Journal of Leprosy and Other Mycobacterial Diseases"},{"issue":"2","key":"e_1_2_10_19_1","first-page":"184","article-title":"Clinical and Histopathological Correlation in Leprosy","volume":"68","author":"Kalla G.","year":"2000","journal-title":"International Journal of Leprosy and Other Mycobacterial Diseases"},{"issue":"4","key":"e_1_2_10_20_1","first-page":"435","article-title":"A Clinico\u2010Pathological Study of Macular Lesions in Leprosy","volume":"66","author":"Kar P. 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