{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:24:51Z","timestamp":1787934291354,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Balamuthia mandrillaris<\/jats:italic>\n                    is a rare cause of cutaneous amebiasis that can progress to central nervous system infection, almost always resulting in death. It is a free\u2010living, opportunistic ameba found globally in dust, soil, and freshwater that can infect people of all ages regardless of the status of the host immune system. Herein, we report a case of\n                    <jats:italic>B. mandrillaris<\/jats:italic>\n                    infection in Canada in an 83\u2010year\u2010old man presenting to the hospital with altered mental status and a chronic wound of 4\u2010year duration. A skin biopsy of the chronic wound revealed extensive dermal granulomatous and mixed inflammatory infiltrate with abundant multinucleated giant cells. Inspection of multiple level sections revealed structures concerning for amebic trophozoites. After the patient's death, lesional tissue from the skin and brain was sent to the Centers for Disease Control (CDC) for further subtyping, which confirmed\n                    <jats:italic>B. mandrillaris<\/jats:italic>\n                    as the causative organism. This case raises awareness for this organism as a possible cause of cutaneous infections and highlights the necessity for dermatopathologists and pathologists alike to have a heightened suspicion for amebic infections when non\u2010specific granulomatous inflammation is identified in the skin.\n                  <\/jats:p>","DOI":"10.1111\/cup.70038","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T04:21:09Z","timestamp":1765772469000},"page":"323-328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hidden in Granulomatous Inflammation: Histopathologic Challenges of Cutaneous\n                    <i>Balamuthia mandrillaris<\/i>\n                    Infection\u2014A Canadian Case Report"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4935-2911","authenticated-orcid":false,"given":"Nicole","family":"Vienneau","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Albany Medical Center  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clayton A.","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Genetics Trillium Health Partners  Mississauga ON Canada"},{"name":"Institute for Better Health, Trillium Health Partners  Mississauga ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohanpal","family":"Dulai","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Genetics Trillium Health Partners  Mississauga ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorne N.","family":"Small","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Trillium Health Partners  Mississauga ON Canada"},{"name":"Faculty of Medicine University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimi T.","family":"Rothrock","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Albany Medical Center  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin","family":"Vanderbeck","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Genetics Trillium Health Partners  Mississauga ON Canada"},{"name":"Department of Pathology and Molecular Medicine Queen's University  Kingston ON 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