{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:53:56Z","timestamp":1773006836316,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, highly aggressive hematologic malignancy characterized by cutaneous involvement with potential dissemination to peripheral blood, bone marrow, lymph nodes, or extranodal sites. We present the first documented case of BPDCN exhibiting complex epigenetic dysregulation in a 54\u2010year\u2010old female who developed rapidly progressive purpuric lesions on the trunk, diagnosed via skin biopsy and immunohistochemistry. Cytogenetic analysis revealed triple molecular aberrations including a\n                    <jats:italic>t<\/jats:italic>\n                    (1;6) (\n                    <jats:italic>p31;q25<\/jats:italic>\n                    ) translocation, a\n                    <jats:italic>TET2<\/jats:italic>\n                    frameshift deletion (44.1% VAF), and a\n                    <jats:italic>KDM6A<\/jats:italic>\n                    missense mutation (\n                    <jats:italic>c.262G&gt;<\/jats:italic>\n                    A, 46.6% VAF). The patient died within 6\u2009months post\u2010diagnosis, suggesting that this aggressive clinical course may be associated with a novel clinicogenetic subtype of BPDCN.\n                  <\/jats:p>","DOI":"10.1111\/cup.70050","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:59:17Z","timestamp":1767401957000},"page":"377-382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Blastic Plasmacytoid Dendritic Cell Neoplasm With De Novo\n                    <scp>TET2<\/scp>\n                    and\n                    <scp>KDM6A<\/scp>\n                    Mutations"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2724-1982","authenticated-orcid":false,"given":"Zixin","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Dermatology, the 1st Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi 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