{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T02:21:09Z","timestamp":1780453269522,"version":"3.54.1"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Immunohistochemistry with T\u2010cell receptor \u03b2\u2010chain constant domain 1 (TRBC1) has been reported to be helpful in distinguishing between a clonal or reactive process. TRBC1 interpretation can be challenging in cases with a low proportion of neoplastic T\u2010cells and high numbers of reactive T\u2010cells. In this study we evaluated TRBC1 immunohistochemistry retrospectively on four cases with known T\u2010cell receptor clonality results by polymerase chain reaction that were clinically categorized as hypopigmented mycosis fungoides. TRBC1 immunohistochemistry was defined as monotypic\u2010negative (TRBC1\u2009&lt;\u200925%, i.e., &lt;\u20091 in 4 positive lymphocytes) or monotypic\u2010positive (TRBC1\u2009&gt;\u200975%, i.e., &gt;\u20093 of 4 lymphocytes positive), or non\u2010monotypic (TRBC1\u2009&gt;\u200925% and &lt;\u200975%). Immunohistochemical results when assessing TRBC1 monotypic expression in the intraepidermal component in all four cases were concordant with T\u2010cell receptor clonality assays. Assessing TRBC1 expression with particular focus on the intraepidermal component may be helpful as a useful data point when evaluating for hypopigmented mycosis fungoides.<\/jats:p>","DOI":"10.1111\/cup.70053","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:24:22Z","timestamp":1767914662000},"page":"414-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Use of\n                    <scp>TRBC1<\/scp>\n                    Immunohistochemistry in the Diagnosis of Hypopigmented Mycosis Fungoides"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1323-2030","authenticated-orcid":false,"given":"Jessica","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Pathology Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gauri","family":"Panse","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University  New Haven Connecticut USA"},{"name":"Department of Dermatology Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2270-2524","authenticated-orcid":false,"given":"Christine J.","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University  New Haven Connecticut USA"},{"name":"Department of Dermatology Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2017.06.006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4444"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21881"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.11.051"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2025.100725"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.15454"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14222479"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010200204000\u201000006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.000014416149294.5a"},{"issue":"1","key":"e_1_2_9_11_1","first-page":"17","article-title":"Vitiligo vs. Hypopigmented Mycosis Fungoides (Histopathological and Immunohistochemical Study, Univariate An\u00e1lisis)","volume":"16","author":"El\u2010Darouti M. A.","year":"2006","journal-title":"European Journal of Dermatology"},{"issue":"4","key":"e_1_2_9_12_1","first-page":"410","article-title":"Inflammatory Vitiligo\u2010Like Macules That Simulate Hypopigmented Mycosis Fungoides","volume":"13","author":"Petit T.","year":"2003","journal-title":"European Journal of Dermatology"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70053","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.70053","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T08:25:48Z","timestamp":1775463948000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.70053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/cup.70053"],"URL":"https:\/\/doi.org\/10.1111\/cup.70053","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,8]]},"assertion":[{"value":"2025-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}