{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:19:15Z","timestamp":1789604355480,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Whipple's disease (WD) is a rare infectious disease caused by\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Tropheryma whipplei<\/jats:italic>\n                    <\/jats:styled-content>\n                    , which primarily affects the gastrointestinal tract but may also involve the joints, central nervous system, and skin. Although cutaneous manifestations are often overlooked, they can provide valuable diagnostic clues. We report the case of a 54\u2010year\u2010old male with long\u2010standing seronegative migratory polyarthritis refractory to conventional treatment, who subsequently developed multiple subcutaneous inflammatory nodules and systemic symptoms. Histopathological examination of these lesions revealed a non\u2010vasculitic, septal\u2010predominant panniculitis with foamy macrophages containing periodic acid\u2010Schiff (PAS)\u2010positive diastase\u2010resistant intracytoplasmic inclusions, raising a strong suspicion of Whipple's disease. Subsequent duodenal biopsies confirmed the diagnosis by electron microscopy and polymerase chain reaction (PCR) for\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>T. whipplei<\/jats:italic>\n                    <\/jats:styled-content>\n                    . Panniculitis in WD represents a highly specific but rarely reported finding, characterized by thickened subcutaneous septa with partial lobular involvement, foamy macrophage infiltration, and absence of vasculitis. A literature review identified 15 cases of histologically confirmed WD\u2010associated panniculitis, suggesting that this manifestation may be under\u2010recognized in clinical practice. This study underscores the importance of cutaneous pathology in WD and expands current knowledge on its dermatological manifestations by providing clinicopathologic, ultrastructural, and literature\u2010based data.\n                  <\/jats:p>","DOI":"10.1111\/cup.70066","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T13:05:49Z","timestamp":1770123949000},"page":"468-474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Whipple's Disease: Panniculitis Among Other Dermatoses. A Case Report and Literature Review"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1624-4142","authenticated-orcid":false,"given":"Alfonso","family":"Ag\u00fcera\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Pathology Department Hospital General Universitario Reina Sof\u00eda  Murcia Spain"},{"name":"University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"del Carmen Brufau\u2010Redondo","sequence":"additional","affiliation":[{"name":"University of Murcia  Murcia Spain"},{"name":"Dermatology Department Hospital General Universitario Reina Sof\u00eda  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6703-9020","authenticated-orcid":false,"given":"Enrique","family":"Poblet","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital General Universitario Reina Sof\u00eda  Murcia Spain"},{"name":"University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"382","article-title":"A Hitherto Undescribed Disease Characterized Anatomically by Deposits of Fat and Fatty Acids in the Intestinal and Mesenteric Lymphatic Tissues","volume":"18","author":"Whipple G. 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