{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T03:05:28Z","timestamp":1779246328471,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Infantile congenital melanocytic nevus (CMN) is a rare type of benign skin lesion originating from neural crest cells. A proliferative nodule (PN) may develop within CMN, and in some cases, atypical proliferative nodules (APNs) with distinct histopathological features may arise, complicating clinical diagnosis and management. This report describes a case of a giant infantile CMN with APN and novel genetic findings, including\n                    <jats:italic>TPR::NTRK1<\/jats:italic>\n                    gene fusion and\n                    <jats:italic>MCL1<\/jats:italic>\n                    amplification. An 8\u2010day\u2010old male presented with a large, uniform, hairless black lesion on the plantar skin. Histological examination revealed nevomelanocytes arranged in a nest\u2010like pattern within the epidermis and dermis. The PN displayed distinct boundaries, with spindle\u2010shaped and oval cells exhibiting pleomorphism, and diffuse infiltration into the subcutaneous fascia and skeletal muscle. Immunohistochemical analysis demonstrated diffuse positivity for HMB45, Melan\u2010A, and S\u2010100 in nevus cells. In the PN, pan\u2010TRK was positive, CD99 showed weak and focal expression, P16 was retained, and PRAME was negative. Genetic analysis revealed a\n                    <jats:italic>TPR::NTRK1<\/jats:italic>\n                    gene fusion and\n                    <jats:italic>MCL1<\/jats:italic>\n                    amplification, suggesting a molecular basis for the atypical features observed in the nodule. This case highlights the role of\n                    <jats:italic>TPR::NTRK1<\/jats:italic>\n                    fusion in driving abnormal melanocyte proliferation and the potential contribution of\n                    <jats:italic>MCL1<\/jats:italic>\n                    amplification to tumor progression. These findings provide insights into the genetic underpinnings of APN in CMN and suggest potential therapeutic targets for high\u2010risk lesions.\n                  <\/jats:p>","DOI":"10.1111\/cup.70067","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T13:04:36Z","timestamp":1770210276000},"page":"475-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Infantile Congenital Nevus With Atypical Proliferative Nodules and\n                    <i>NTRK<\/i>\n                    Gene Fusion"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8720-6754","authenticated-orcid":false,"given":"Shuang","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Pathology Henan Provincial People's Hospital, the People's Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxia","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology Henan Provincial People's Hospital, the People's Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pathology Henan Provincial People's Hospital, the People's Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Henan Provincial People's Hospital, the People's Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shasha","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pathology Henan Provincial People's Hospital, the People's Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pathology Henan Provincial People's Hospital, the People's Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juntao","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Henan Provincial People's Hospital, the People's Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangfang","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Image Henan Provincial People's Hospital, the People's Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1645-3365","authenticated-orcid":false,"given":"Qiuyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology Henan Provincial People's Hospital, the People's Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15182"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.2667"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.7181\/acfs.2019.00045"},{"issue":"9","key":"e_1_2_7_5_1","first-page":"609","article-title":"Proliferative Nodules in Congenital Melanocytic Nevi: A Clinicopathological Analysis of Eight Cases","volume":"43","author":"Kong Y.","year":"2014","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-019-0797-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01431.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31821375ea"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64393-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001134"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000769"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-22517"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.70"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12785"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.08.2232"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14069"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0324-7"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2019.03.008"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.14822"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1226289"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.70067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:05:32Z","timestamp":1779242732000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.70067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,4]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/cup.70067"],"URL":"https:\/\/doi.org\/10.1111\/cup.70067","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,4]]},"assertion":[{"value":"2025-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}